Xu Er, Ji Bangju, Jin Ketao, Chen Yefeng
Department of Hospital Infection Management, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China.
Department of Colorectal Surgery, Shaoxing People's Hospital, Shaoxing, Zhejiang, China.
Front Oncol. 2023 Aug 10;13:1220638. doi: 10.3389/fonc.2023.1220638. eCollection 2023.
Branched-chain amino acids (BCAAs), including valine, leucine, and isoleucine, are crucial amino acids with significant implications in tumorigenesis across various human malignancies. Studies have demonstrated that altered BCAA metabolism can influence tumor growth and progression. Increased levels of BCAAs have been associated with tumor growth inhibition, indicating their potential as anti-cancer agents. Conversely, a deficiency in BCAAs can promote tumor metastasis to different organs due to the disruptive effects of high BCAA concentrations on tumor cell migration and invasion. This disruption is associated with tumor cell adhesion, angiogenesis, metastasis, and invasion. Furthermore, BCAAs serve as nitrogen donors, contributing to synthesizing macromolecules such as proteins and nucleotides crucial for cancer cell growth. Consequently, BCAAs exhibit a dual role in cancer, and their effects on tumor growth or inhibition are contingent upon various conditions and concentrations. This review discusses these contrasting findings, providing valuable insights into BCAA-related therapeutic interventions and ultimately contributing to a better understanding of their potential role in cancer treatment.
支链氨基酸（BCAAs），包括缬氨酸、亮氨酸和异亮氨酸，是关键氨基酸，在多种人类恶性肿瘤的肿瘤发生过程中具有重要意义。研究表明，BCAA代谢的改变会影响肿瘤的生长和进展。BCAAs水平升高与肿瘤生长抑制有关，表明它们具有作为抗癌药物的潜力。相反，由于高浓度BCAAs对肿瘤细胞迁移和侵袭的破坏作用，BCAAs缺乏会促进肿瘤向不同器官转移。这种破坏与肿瘤细胞黏附、血管生成、转移和侵袭有关。此外，BCAAs作为氮供体，有助于合成对癌细胞生长至关重要的大分子，如蛋白质和核苷酸。因此，BCAAs在癌症中表现出双重作用，它们对肿瘤生长或抑制的影响取决于各种条件和浓度。本综述讨论了这些相互矛盾的发现，为与BCAA相关的治疗干预提供了有价值的见解，并最终有助于更好地理解它们在癌症治疗中的潜在作用。
