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将基于石墨烯的材料的物理化学性质与分子吸附、结构及细胞命运联系起来。

Linking graphene-based material physicochemical properties with molecular adsorption, structure and cell fate.

作者信息

Kumar Sachin, Parekh Sapun H

机构信息

Department of Biomedical Engineering, University of Texas at Austin, 107 W. Dean Keeton Rd., Austin, TX, 78712, USA.

Department of Molecular Spectroscopy, Max Planck Institute for Polymer Research, Ackermannweg 10, D-55128, Mainz, DE, USA.

出版信息

Commun Chem. 2020 Jan 20;3(1):8. doi: 10.1038/s42004-019-0254-9.

DOI:10.1038/s42004-019-0254-9
PMID:36703309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9814659/
Abstract

Graphene, an allotrope of carbon, consists of a single layer of carbon atoms with uniquely tuneable properties. As such, graphene-based materials (GBMs) have gained interest for tissue engineering applications. GBMs are often discussed in the context of how different physicochemical properties affect cell physiology, without explicitly considering the impact of adsorbed proteins. Establishing a relationship between graphene properties, adsorbed proteins, and cell response is necessary as these proteins provide the surface upon which cells attach and grow. This review highlights the molecular adsorption of proteins on different GBMs, protein structural changes, and the connection to cellular function.

摘要

石墨烯是碳的一种同素异形体，由具有独特可调性质的单层碳原子组成。因此，基于石墨烯的材料（GBMs）在组织工程应用中受到了关注。人们在讨论GBMs时，通常关注不同的物理化学性质如何影响细胞生理，而没有明确考虑吸附蛋白的影响。由于这些蛋白提供了细胞附着和生长的表面，因此有必要建立石墨烯性质、吸附蛋白和细胞反应之间的关系。本综述重点介绍了蛋白在不同GBMs上的分子吸附、蛋白结构变化以及与细胞功能的联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/5475dc72e590/42004_2019_254_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/5e201286d231/42004_2019_254_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/8c489a8fa01a/42004_2019_254_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/cd6afda9a83c/42004_2019_254_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/4c6dbae92338/42004_2019_254_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/a1b535ae22dc/42004_2019_254_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/fc8cb220afba/42004_2019_254_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/5475dc72e590/42004_2019_254_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/5e201286d231/42004_2019_254_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/8c489a8fa01a/42004_2019_254_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/cd6afda9a83c/42004_2019_254_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/4c6dbae92338/42004_2019_254_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/a1b535ae22dc/42004_2019_254_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/fc8cb220afba/42004_2019_254_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0870/9814659/5475dc72e590/42004_2019_254_Fig7_HTML.jpg

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本文引用的文献

[1]
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Mater Sci Eng C Mater Biol Appl. 2018-5-5

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Nanoscale. 2016-3-28

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