Ben Ammar Teissir, Kharouf Naji, Vautier Dominique, Ba Housseinou, Sudheer Nivedita, Lavalle Philippe, Ball Vincent
INSERM UMR_S 1121, CNRS EMR 7003, Université de Strasbourg, Biomaterials and Bioengineering, Centre de Recherche en Biomédecine de Strasbourg, 1 rue Eugène Boeckel, Strasbourg F-67000, France.
Blackleaf, Illkirch-Graffenstaden, 67400, France.
Beilstein J Nanotechnol. 2025 May 20;16:664-677. doi: 10.3762/bjnano.16.51. eCollection 2025.
Dental diseases pose a global health concern. In addition to medication and care, the use of biocompatible and even bioactive dental materials can contribute to global oral health. Among such materials, nanomaterials begin to be used. In this context, the incorporation of graphene-based materials into dental biomaterials could offer advantages such as increased mechanical strength. Nevertheless, biocompatibility issues still hinder their adoption. In this study, a biocomposite of few-layered graphene and tannic acid (FLG-TA) was synthesized through a straightforward, bio-based methodology. Physicochemical characterizations elucidated the structural and morphological attributes of the biocomposite. By incorporating antioxidant TA molecules onto the FLG surface, the biocomposite dynamically mitigated reactive oxygen species, demonstrating no cytotoxicity to periodontal ligament cells up to 200 µg·mL while promoting cellular adhesion and maintaining chromatin integrity. Overall, because of its favorable biocompatibility FLG-TA holds promise as a novel biomaterial for dental applications.
牙科疾病是一个全球健康问题。除了药物治疗和护理外，使用生物相容性甚至生物活性的牙科材料有助于全球口腔健康。在这类材料中，纳米材料开始得到应用。在这种背景下，将基于石墨烯的材料纳入牙科生物材料中可能会带来诸如提高机械强度等优势。然而，生物相容性问题仍然阻碍它们的应用。在本研究中，通过一种简单的生物基方法合成了少层石墨烯与单宁酸的生物复合材料（FLG-TA）。物理化学表征阐明了该生物复合材料的结构和形态特征。通过将抗氧化的TA分子结合到FLG表面，该生物复合材料动态减轻了活性氧，在高达200 µg·mL时对牙周膜细胞无细胞毒性，同时促进细胞黏附并维持染色质完整性。总体而言，由于其良好的生物相容性，FLG-TA有望成为一种新型的牙科应用生物材料。
