Shimizu M, Yano E
Department of Environmental Health, Faculty of Health Sciences, University of Kyorin, Japan.
Mutat Res. 1987 Nov;189(3):307-11. doi: 10.1016/0165-1218(87)90062-0.
The mutagenicity of instant coffee and its interaction with dimethylnitrosamine (DMN) were examined in mice using the micronucleus test. Although neither a single nor multiple administration of instant coffee by gavage induced a significant rise in micronucleated cells over the dose range tested (100-2500 mg/kg), there was a tendency for the number of micronucleated cells to increase in a dose-related fashion. When coffee was administered with DMN, the difference in the frequency of micronucleated cells was small in comparison to a single treatment with DMN alone, thus indicating a lack of synergism between coffee and DMN.
