Borghi Sergio M, Zaninelli Tiago H, Saraiva-Santos Telma, Bertozzi Mariana M, Cardoso Renato D R, Carvalho Thacyana T, Ferraz Camila R, Camilios-Neto Doumit, Cunha Fernando Q, Cunha Thiago M, Pinho-Ribeiro Felipe A, Casagrande Rubia, Verri Waldiceu A
Department of Pathology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil.
Center for Research in Health Science, University of Northern Paraná, Londrina, Brazil.
Front Pharmacol. 2023 Jan 10;13:950314. doi: 10.3389/fphar.2022.950314. eCollection 2022.
In this study, we pursue determining the effect of pentoxifylline (Ptx) in delayed-onset muscle soreness (DOMS) triggered by exposing untrained mice to intense acute swimming exercise (120 min), which, to our knowledge, has not been investigated. Ptx treatment (1.5, 4.5, and 13.5 mg/kg; i.p., 30 min before and 12 h after the session) reduced intense acute swimming-induced mechanical hyperalgesia in a dose-dependent manner. The selected dose of Ptx (4.5 mg/kg) inhibited recruitment of neutrophils to the muscle tissue, oxidative stress, and both pro- and anti-inflammatory cytokine production in the soleus muscle and spinal cord. Furthermore, Ptx treatment also reduced spinal cord glial cell activation. In conclusion, Ptx reduces pain by targeting peripheral and spinal cord mechanisms of DOMS.
在本研究中，我们致力于确定己酮可可碱（Ptx）对未训练小鼠进行剧烈急性游泳运动（120分钟）引发的延迟性肌肉酸痛（DOMS）的影响，据我们所知，此前尚未对此进行过研究。Ptx治疗（1.5、4.5和13.5毫克/千克；腹腔注射，在运动前30分钟和运动后12小时）以剂量依赖的方式减轻了剧烈急性游泳诱导的机械性痛觉过敏。所选剂量的Ptx（4.5毫克/千克）抑制了中性粒细胞向肌肉组织的募集、氧化应激以及比目鱼肌和脊髓中促炎和抗炎细胞因子的产生。此外，Ptx治疗还减少了脊髓胶质细胞的激活。总之，Ptx通过针对DOMS的外周和脊髓机制减轻疼痛。
