Fu Hongyan, Sun Shaofeng, Zhang Hong, Chi Shuhong, Ma Weirong, Yang Guilan, Chen Juan
Department of Pulmonary and Critical Care Medicine General Hospital of Ningxia Medical University Yinchuan, Ningxia China.
Ningxia Medical University Ningxia China.
Clin Case Rep. 2023 Jan 23;11(1):e6840. doi: 10.1002/ccr3.6840. eCollection 2023 Jan.
Coexisting anti-MDA5 and anti-PL-7 antibodies are extremely rare. Anti-MDA5 is associated with rapidly progressive interstitial lung disease (RP-ILD), while anti-PL-7 is often associated with chronic or subacute ILD and better outcomes than RP-ILD. We report a 41-year-old woman diagnosed with dermatomyositis (DM)-associated ILD positive for anti-MDA5 and anti-PL-7.
抗黑色素瘤分化相关基因5（MDA5）抗体和抗苏氨酰-tRNA合成酶（PL-7）抗体同时存在极为罕见。抗MDA5与快速进展性间质性肺病（RP-ILD）相关，而抗PL-7通常与慢性或亚急性间质性肺病相关，且预后比RP-ILD好。我们报告了一名41岁女性，诊断为抗MDA5和抗PL-7阳性的皮肌炎（DM）相关间质性肺病。
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