Khademi Abbasali, Memarzadeh Bahareh, Saatchi Masoud, Aggarwal Vivek, Shafiee Maryam, Minaiyan Mohsen, Omranifard Victoria
Department of Endodontics, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Endodontics, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Iran Endod J. 2022 Spring;17(2):52-56. doi: 10.22037/iej.v17i2.34921.
This study sought to evaluate the success rate of inferior alveolar nerve block (IANB) during the endodontic management of mandibular molars with symptomatic irreversible pulpitis in women taking selective serotonin reuptake inhibitor (SSRI) antidepressants.
Ninety adult female patients over 18 years of age who were diagnosed with symptomatic irreversible pulpitis of a mandibular molar were recruited in this study. The patients were equally assigned to SSRI user group (including citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), who had taken an SSRI, and non-SSRI user group, who had not taken any SSRIs at all. All patients in both groups received 3.6 mL of 2% lidocaine with 1:80,000 epinephrine using conventional IANB injection. Access cavity was prepared 15 min after the injection. Lip numbness was necessary for all patients. Success was determined as no or mild pain upon access cavity preparation and/or instrumentation based on the Heft-Parker visual analog scale recordings. Data were analyzed using the chi-square test Mann-Whitney U test, and -test.
The success rate was 55.6% for SSRI users and 44.4% for non-SSRI users, and no statistically significant difference was observed between the two groups ( =1.1=0.292).
Based on the results of this study, taking SSRI antidepressants could not affect the anesthetic success rate of IANB for mandibular molars with symptomatic irreversible pulpitis in women.
本研究旨在评估在患有症状性不可逆性牙髓炎的下颌磨牙根管治疗过程中，服用选择性5-羟色胺再摄取抑制剂（SSRI）类抗抑郁药的女性患者下牙槽神经阻滞（IANB）的成功率。
本研究招募了90名18岁以上被诊断患有下颌磨牙症状性不可逆性牙髓炎的成年女性患者。患者被平均分配至服用SSRI的SSRI使用者组（包括西酞普兰、艾司西酞普兰、氟西汀、氟伏沙明、帕罗西汀和舍曲林）和未服用任何SSRI的非SSRI使用者组。两组所有患者均采用传统IANB注射法注射3.6 mL含1:80,000肾上腺素的2%利多卡因。注射15分钟后制备开髓腔。所有患者均需出现唇部麻木。根据Heft-Parker视觉模拟量表记录，开髓腔制备和/或器械操作时无痛或轻度疼痛则判定为成功。数据采用卡方检验、曼-惠特尼U检验和t检验进行分析。
SSRI使用者组成功率为55.6%，非SSRI使用者组成功率为44.4%，两组间未观察到统计学显著差异（P = 1.1，P = 0.292）。
基于本研究结果，服用SSRI类抗抑郁药不会影响患有症状性不可逆性牙髓炎的女性下颌磨牙IANB的麻醉成功率。
