Kovács Beáta, Németh Ákos, Daróczy Bálint, Karányi Zsolt, Maroda László, Diószegi Ágnes, Nádró Bíborka, Szabó Tamás, Harangi Mariann, Páll Dénes
Division of Metabolic Disorders, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Institute for Computer Science and Control, Eötvös Loránd Research Network (ELKH SZTAKI), Budapest, Hungary.
Front Cardiovasc Med. 2023 Jan 10;9:1081986. doi: 10.3389/fcvm.2022.1081986. eCollection 2022.
Identifying hypertension in children and providing treatment for it have a marked impact on the patients' long-term cardiovascular outcomes. The global prevalence of childhood hypertension is increasing, yet its investigation has been rather sporadic in Eastern Europe. Therefore, our goal was to determine the prevalence of childhood hypertension and its concomitant metabolic abnormalities using data mining methods.
We evaluated data from 3 to 18-year-old children who visited the University of Debrecen Clinical Center's hospital throughout a 15-year study period ( = 92,198; boys/girls: 48/52%).
We identified a total of 3,687 children with hypertension (2,107 boys and 1,580 girls), with a 4% calculated prevalence of hypertension in the whole study population and a higher prevalence in boys (4.7%) as compared to girls (3.2%). Among boys we found an increasing prevalence in consecutive age groups in the study population, but among girls the highest prevalences are identified in the 12-15-year age group. Markedly higher BMI values were found in hypertensive children as compared to non-hypertensives in all age groups. Moreover, significantly higher total cholesterol (4.27 ± 0.95 vs. 4.17 ± 0.88 mmol/L), LDL-C (2.62 ± 0.79 vs. 2.44 ± 0.74 mmol/L) and triglyceride (1.2 (0.85-1.69) vs. 0.94 (0.7-1.33) mmol/L), and lower HDL-C (1.2 ± 0.3 vs. 1.42 ± 0.39 mmol/L) levels were found in hypertensive children. Furthermore, significantly higher serum uric acid levels were found in children with hypertension (299.2 ± 86.1 vs. 259.9 ± 73.3 μmol/L), while glucose levels did not differ significantly.
Our data suggest that the calculated prevalence of childhood hypertension in our region is comparable to data from other European countries and is associated with early metabolic disturbances. Data mining is an effective method for identifying childhood hypertension and its metabolic consequences.
识别儿童高血压并给予治疗对患者长期心血管结局有显著影响。儿童高血压的全球患病率正在上升，但在东欧其调查一直较为零散。因此，我们的目标是使用数据挖掘方法确定儿童高血压的患病率及其伴随的代谢异常情况。
我们评估了在15年研究期间就诊于德布勒森大学临床中心医院的3至18岁儿童的数据（n = 92,198；男孩/女孩：48/52%）。
我们共识别出3687名高血压儿童（2107名男孩和1580名女孩），整个研究人群中高血压的计算患病率为4%，男孩患病率（4.7%）高于女孩（3.2%）。在研究人群中，我们发现男孩连续年龄组的患病率呈上升趋势，但女孩中患病率最高的是12至15岁年龄组。在所有年龄组中，高血压儿童的BMI值明显高于非高血压儿童。此外，高血压儿童的总胆固醇（4.27±0.95 vs. 并给予治疗对患者长期心血管结局有显著影响。儿童高血压的全球患病率正在上升，但在东欧其调查一直较为零散。因此，我们的目标是使用数据挖掘方法确定儿童高血压的患病率及其伴随的代谢异常情况。
我们评估了在15年研究期间就诊于德布勒森大学临床中心医院的3至18岁儿童的数据（n = 92,198；男孩/女孩：48/52%）。
我们共识别出3687名高血压儿童（2107名男孩和1580名女孩），整个研究人群中高血压的计算患病率为4%，男孩患病率（4.7%）高于女孩（3.2%）。在研究人群中，我们发现男孩连续年龄组的患病率呈上升趋势，但女孩中患病率最高的是12至15岁年龄组。在所有年龄组中，高血压儿童的BMI值明显高于非高血压儿童。此外，高血压儿童的总胆固醇（4.27±0.95 vs. 4.17±0.88 mmol/L）、低密度脂蛋白胆固醇（2.62±0.79 vs. 2.44±0.74 mmol/L）和甘油三酯（1.2（0.85 - 1.69）vs. 0.94（0.7 - 1.33）mmol/L）水平显著更高，而高密度脂蛋白胆固醇水平更低（1.2±0.3 vs. 1.42±0.39 mmol/L）。此外，高血压儿童的血清尿酸水平显著更高（299.2±86.1 vs. 259.9±73.3 μmol/L），而血糖水平无显著差异。
我们的数据表明，我们地区儿童高血压的计算患病率与其他欧洲国家的数据相当，且与早期代谢紊乱有关。数据挖掘是识别儿童高血压及其代谢后果的有效方法。
