Kovács Beáta, Németh Ákos, Daróczy Bálint, Karányi Zsolt, Maroda László, Diószegi Ágnes, Harangi Mariann, Páll Dénes
Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Institute for Computer Science and Control (SZTAKI), Hungarian Research Network, H-1111 Budapest, Hungary.
J Cardiovasc Dev Dis. 2023 Aug 13;10(8):345. doi: 10.3390/jcdd10080345.
Cardiovascular diseases are among the leading causes of mortality worldwide. Hypertension is a preventable risk factor leading to major cardiovascular events. We have not found a comprehensive study investigating Central and Eastern European hypertensive patients' complex metabolic status. Therefore, our goal was to calculate the prevalence of hypertension and associated metabolic abnormalities using data-mining methods in our region. We assessed the data of adults who visited the University of Debrecen Clinical Center's hospital (n = 937,249). The study encompassed data from a period of 20 years (2001-2021). We detected 292,561 hypertensive patients. The calculated prevalence of hypertension was altogether 32.2%. Markedly higher body mass index values were found in hypertensive patients as compared to non-hypertensives. Significantly higher triglyceride and lower HDL-C levels were found in adults from 18 to 80 years old. Furthermore, significantly higher serum glucose and uric acid levels were measured in hypertensive subjects. Our study confirms that the calculated prevalence of hypertension is akin to international findings and highlights the extensive association of metabolic alterations. These findings emphasize the role of early recognition and immediate treatment of cardiometabolic abnormalities to improve the quality of life and life expectancy of hypertensive patients.
心血管疾病是全球主要死因之一。高血压是导致重大心血管事件的可预防风险因素。我们尚未发现一项全面研究中欧和东欧高血压患者复杂代谢状况的研究。因此，我们的目标是使用数据挖掘方法计算我们地区高血压及相关代谢异常的患病率。我们评估了前往德布勒森大学临床中心医院就诊的成年人的数据（n = 937,249）。该研究涵盖了20年（2001 - 2021年）期间的数据。我们检测到292,561名高血压患者。计算得出的高血压总体患病率为32.2%。与非高血压患者相比，高血压患者的体重指数值明显更高。在18至80岁的成年人中，甘油三酯水平显著更高，高密度脂蛋白胆固醇水平更低。此外，高血压患者的血清葡萄糖和尿酸水平显著更高。我们的研究证实，计算得出的高血压患病率与国际研究结果相近，并突出了代谢改变的广泛关联。这些发现强调了早期识别和立即治疗心脏代谢异常对于改善高血压患者生活质量和预期寿命的作用。
