Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Florence, Italy.
Department of Pathology, Medical University of Vienna, General Hospital of Vienna, Wien, AT, Austria.
Pathologica. 2022 Feb;115(1):32-40. doi: 10.32074/1591-951X-838. Epub 2023 Jan 25.
The fifth-edition of World Health Organization (WHO) Classification of Tumors series for urinary and male genital tract tumors has been published, six years later the fourth-edition. In these years, new treatment approaches have been implemented and new molecular data on urological cancers are known. Morphology remains the groundwork for taxonomy of the urinary tract tumors. However, a molecular approach to classification of urothelial carcinomas and the management of selected neoplasms with new therapeutic modalities such as immunotherapy are emerging. More data are needed for the application of these advances in routine pathology practice and patient management. The 2022 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs represents an update in classification on urinary tract tumors. It also offers new insights with regards to the grading of heterogeneous non-invasive urothelial neoplasms, the definition of inverted neoplasms, the grading of invasive urothelial carcinomas, the diversity of morphological appearance of urothelial carcinomas, the definition of precursor lesions and the lineage of differentiation of the tumors.
世界卫生组织（WHO）第五版泌尿系统和男性生殖系统肿瘤分类在第四版出版六年后发布。在这几年中，已经实施了新的治疗方法，并且在泌尿系统癌症方面有了新的分子数据。形态学仍然是泌尿系统肿瘤分类的基础。然而，针对尿路上皮癌的分类的分子方法以及针对具有新治疗方式（如免疫疗法）的选定肿瘤的管理正在出现。需要更多的数据来将这些进展应用于常规病理实践和患者管理中。2022 年世界卫生组织（WHO）泌尿系统和男性生殖器官肿瘤分类代表了泌尿系统肿瘤分类的更新。它还提供了关于异质性非浸润性尿路上皮肿瘤分级、倒置肿瘤的定义、浸润性尿路上皮癌分级、尿路上皮癌形态多样性、前体病变的定义以及肿瘤分化谱系的新见解。
