Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
Kanti Childrens Hospital, Maharajgunj, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2022 Dec 1;60(256):1059-1062. doi: 10.31729/jnma.7808.
Autoimmune hepatitis is a rare form of chronic liver inflammation that begins as acute hepatitis and progresses to chronic liver disease. It presents with varied clinical features from acute hepatitis to chronic liver diseases like chronic viral hepatitis and alcoholic liver disease, making it difficult to diagnose in the absence of a high index of suspicion and adequate laboratory support. Autoimmune hepatitis is divided into two categories autoimmune hepatitis-1 and autoimmune hepatitis-2 based on the antibodies involved. We discuss the case of a 37-year-old woman who developed autoimmune hepatitis-1, with swelling and epigastric pain. These symptoms later progressed to liver cirrhosis leading to the death of the patient. Autoimmune hepatitis is extremely sensitive to immunosuppressive medication, it is necessary to maintain a high suspicion index for the disease because a prompt diagnosis can be an integral step toward a better prognosis of the disease.
autoimmune hepatitis; case reports; chronic hepatitis; liver cirrhosis.
自身免疫性肝炎是一种罕见的慢性肝脏炎症，由急性肝炎开始发展为慢性肝病。它的临床表现从急性肝炎到慢性病毒性肝炎和酒精性肝病等慢性肝病各不相同，因此如果没有高度怀疑和充分的实验室支持，诊断起来很困难。根据涉及的抗体，自身免疫性肝炎分为自身免疫性肝炎-1 和自身免疫性肝炎-2 两种类型。我们讨论了一位 37 岁女性的病例，她患有自身免疫性肝炎-1，出现肿胀和上腹痛。这些症状后来进展为肝硬化，导致患者死亡。自身免疫性肝炎对免疫抑制药物非常敏感，因此有必要对该病保持高度怀疑指数，因为及时诊断是改善疾病预后的重要步骤。
自身免疫性肝炎；病例报告；慢性肝炎；肝硬化。
