School of Sports, Wuhan University of Science and Technology, Wuhan, China.
Tennis College, Wuhan sports university, Wuhan, China.
Medicine (Baltimore). 2023 Jan 27;102(4):e32814. doi: 10.1097/MD.0000000000032814.
Many people have experienced a high burden due to the spread of the coronavirus disease (COVID-19) and its serious consequences for health and everyday life. Prior studies have reported that physical activity (PA) may lower the risk of COVID-19 hospitalization. The present meta-analysis explored the dose-response relationship between PA and the risk of COVID-19 hospitalization.
Epidemiological observational studies on the relationship between PA and the risk of COVID-19 hospitalization were included. Categorical dose-response relationships between PA and the risk of COVID-19 hospitalization were assessed using random effect models. Robust error meta-regression models assessed the continuous relationship between PA (metabolic equivalent [Met]-h/wk) and COVID-19 hospitalization risk across studies reporting quantitative PA estimates.
Seventeen observational studies (cohort\case-control\cross-section) met the criteria for inclusion in the meta-analysis. Categorical dose-relationship analysis showed a 40% (risk ratio [RR] 0.60, 95% confidence interval [CI]: 0.48-0.71) reduction in the risk of COVID-19 hospitalization compared to the lowest dose of PA. The results of the continuous dose-response relationship showed a non-linear inverse relationship (Pnon-linearity < .05) between PA and the risk of COVID-19 hospitalization. When total PA was < or >10 Met-h/wk, an increase of 4 Met-h/wk was associated with a 14% (RR = 0.83, 95% CI: 0.85-0.87) and 11% (RR = 0.89, 95% CI: 0.87-0.90) reduction in the risk of COVID-19 hospitalization, respectively.
There was an inverse non-linear dose-response relationship between PA level and the risk of COVID-19 hospitalization. Doses of the guideline-recommended minimum PA levels by the World Health Organization may be required for more substantial reductions in the COVID-19 hospitalization risk.
由于冠状病毒病 (COVID-19) 的传播及其对健康和日常生活的严重影响，许多人负担沉重。先前的研究报告称，身体活动 (PA) 可能降低 COVID-19 住院的风险。本荟萃分析探讨了 PA 与 COVID-19 住院风险之间的剂量反应关系。
纳入了关于 PA 与 COVID-19 住院风险关系的流行病学观察性研究。使用随机效应模型评估 PA 与 COVID-19 住院风险之间的分类剂量反应关系。稳健误差荟萃回归模型评估了报告定量 PA 估计值的研究中 PA（代谢当量 [Met]-h/wk）与 COVID-19 住院风险之间的连续关系。
17 项观察性研究（队列/病例对照/横断面）符合纳入荟萃分析的标准。分类剂量关系分析显示，与最低 PA 剂量相比，COVID-19 住院风险降低 40%（风险比 [RR] 0.60，95%置信区间 [CI]：0.48-0.71）。连续剂量反应关系的结果表明，PA 与 COVID-19 住院风险之间呈非线性反比关系（P 非线性<.05）。当总 PA<或>10 Met-h/wk 时，PA 每增加 4 Met-h/wk，与 COVID-19 住院风险降低 14%（RR=0.83，95%CI：0.85-0.87）和 11%（RR=0.89，95%CI：0.87-0.90）相关。
PA 水平与 COVID-19 住院风险之间存在非线性反比关系。可能需要达到世界卫生组织推荐的最低 PA 水平的指南剂量，以更大程度地降低 COVID-19 住院风险。
