Khzam Afif, Saunier Johanna, Carpentier Léa, Mignot Agnès, Tortolano Lionel, Yagoubi Najet
Matériaux et Santé, UFR de pharmacie, Université Paris-Saclay, Orsay, France.
Vygon, Ecouen, France.
J Biomed Mater Res B Appl Biomater. 2023 Jun;111(6):1182-1196. doi: 10.1002/jbm.b.35224. Epub 2023 Jan 27.
This article investigates the impact of the interactions between polyurethane central venous catheters and solutions containing excipients used in cisplatin and paclitaxel formulations. Changes to the properties of catheters and the leaching of catheter additives into the infused solutions were studied while these solutions were infused cyclically for several months. Chemotherapy treatment was mimicked in vitro in compliance with hospital practices. The treatment cycle was repeated 10 times, using solutions containing only the excipients. After 10 treatment cycles, no physical or chemical degradation of the catheter was observed. Mechanical performances were stable, but surface modifications occurred, causing the surface to become more hydrophobic. A loss in polyurethane antioxidant amount was observed in part due to a leaching phenomenon.
本文研究了聚氨酯中心静脉导管与顺铂和紫杉醇制剂中所用含辅料溶液之间相互作用的影响。在这些溶液循环输注数月的过程中，研究了导管性能的变化以及导管添加剂向输注溶液中的浸出情况。按照医院的操作规范在体外模拟化疗治疗。使用仅含辅料的溶液将治疗周期重复10次。在10个治疗周期后，未观察到导管有物理或化学降解。机械性能稳定，但发生了表面改性，使表面变得更疏水。部分由于浸出现象，观察到聚氨酯抗氧化剂含量有所损失。
