Kubota M, Namba H, Sunami K, Yamaura A, Makino H, Murano S, Nishikawa T, Oheda T, Saito Y, Yoshida S
Department of Neurological Surgery, School of Medicine, Chiba University, Japan.
Neuropharmacology. 1987 Sep;26(9):1403-8. doi: 10.1016/0028-3908(87)90106-7.
The effects of mazindol (1 mg or 10 mg/animal, p.o.) on local cerebral utilization of glucose were studied by the quantitative autoradiographic [14C]2-deoxyglucose method in conscious adult male rats. Significant increases in local cerebral utilization of glucose were observed 2 hr after administration of 10 mg of mazindol in 10 out of 37 anatomically discrete regions examined. These 10 areas included regions rich in dopaminergic receptors (substantia nigra, globus pallidus), and also regions with few dopaminergic receptors (cerebral cortex, thalamus, cerebellum). Only the habenular nucleus showed a significant decrease in utilization of glucose induced by the administration of 10 mg of mazindol. No significant changes in local cerebral utilization of glucose were observed following the administration of 1 mg of mazindol. The fact that the pattern of utilization of glucose observed in this study resembled that produced by apomorphine, a putative dopaminergic agonist, indicates that the pharmacological effects of mazindol are related to the dopaminergic system.
采用定量放射自显影[14C]2-脱氧葡萄糖法，在成年雄性清醒大鼠中研究了吗吲哚（1毫克或10毫克/动物，口服）对局部脑葡萄糖利用的影响。在检测的37个解剖学离散区域中的10个区域，给予10毫克吗吲哚2小时后，观察到局部脑葡萄糖利用显著增加。这10个区域包括富含多巴胺能受体的区域（黑质、苍白球），以及多巴胺能受体较少的区域（大脑皮层、丘脑、小脑）。仅缰核在给予10毫克吗吲哚后显示葡萄糖利用显著降低。给予1毫克吗吲哚后，未观察到局部脑葡萄糖利用有显著变化。本研究中观察到的葡萄糖利用模式与推测的多巴胺能激动剂阿扑吗啡所产生的模式相似，这一事实表明吗吲哚的药理作用与多巴胺能系统有关。
