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基于点云的浅层白质分析:一种高效的监督对比学习深度学习框架,用于在人群和 dMRI 采集之间实现一致的轨迹分段。

Superficial white matter analysis: An efficient point-cloud-based deep learning framework with supervised contrastive learning for consistent tractography parcellation across populations and dMRI acquisitions.

机构信息

Brigham and Women's Hospital, Harvard Medical School, Boston, USA; School of Computer Science, University of Sydney, Sydney, Australia.

Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

出版信息

Med Image Anal. 2023 Apr;85:102759. doi: 10.1016/j.media.2023.102759. Epub 2023 Jan 23.


DOI:10.1016/j.media.2023.102759
PMID:36706638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9975054/
Abstract

Diffusion MRI tractography is an advanced imaging technique that enables in vivo mapping of the brain's white matter connections. White matter parcellation classifies tractography streamlines into clusters or anatomically meaningful tracts. It enables quantification and visualization of whole-brain tractography. Currently, most parcellation methods focus on the deep white matter (DWM), whereas fewer methods address the superficial white matter (SWM) due to its complexity. We propose a novel two-stage deep-learning-based framework, Superficial White Matter Analysis (SupWMA), that performs an efficient and consistent parcellation of 198 SWM clusters from whole-brain tractography. A point-cloud-based network is adapted to our SWM parcellation task, and supervised contrastive learning enables more discriminative representations between plausible streamlines and outliers for SWM. We train our model on a large-scale tractography dataset including streamline samples from labeled long- and medium-range (over 40 mm) SWM clusters and anatomically implausible streamline samples, and we perform testing on six independently acquired datasets of different ages and health conditions (including neonates and patients with space-occupying brain tumors). Compared to several state-of-the-art methods, SupWMA obtains highly consistent and accurate SWM parcellation results on all datasets, showing good generalization across the lifespan in health and disease. In addition, the computational speed of SupWMA is much faster than other methods.

摘要

弥散磁共振成像轨迹追踪是一种先进的成像技术,能够在体绘制大脑白质连接。白质分割将轨迹追踪流线分类为簇或具有解剖意义的束。它能够对全脑轨迹追踪进行量化和可视化。目前,大多数分割方法侧重于深部白质(DWM),而由于其复杂性,较少的方法涉及浅层白质(SWM)。我们提出了一种新颖的基于深度学习的两阶段框架,即浅层白质分析(SupWMA),可对全脑轨迹追踪中的 198 个 SWM 簇进行高效且一致的分割。我们采用基于点云的网络来完成 SWM 分割任务,并且监督对比学习能够在 SWM 的似然流线和异常值之间产生更具判别力的表示。我们在包括标记的长程和中程(超过 40mm)SWM 簇以及解剖上不合理的流线样本的大规模轨迹追踪数据集上对我们的模型进行训练,并在六个不同年龄和健康状况的独立采集数据集上进行测试(包括新生儿和患有占位性脑肿瘤的患者)。与几种最先进的方法相比,SupWMA 在所有数据集上都获得了高度一致和准确的 SWM 分割结果,在健康和疾病的整个生命周期中都表现出良好的泛化能力。此外,SupWMA 的计算速度比其他方法快得多。

相似文献

[1]
Superficial white matter analysis: An efficient point-cloud-based deep learning framework with supervised contrastive learning for consistent tractography parcellation across populations and dMRI acquisitions.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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引用本文的文献

[1]
Imaging of the superficial white matter in health and disease.

Imaging Neurosci (Camb). 2024-7-22

[2]
The superficial white matter in language processing: Broca's area connections are bilaterally associated with individual performance in children and adults.

bioRxiv. 2025-8-1

[3]
Think deep in the tractography game: deep learning for tractography computing and analysis.

Brain Struct Funct. 2025-6-16

[4]
Short association fiber tractography: key insights and surprising facts.

Brain Struct Funct. 2025-6-14

[5]
A review on learning-based algorithms for tractography and human brain white matter tracts recognition.

Neuroradiology. 2025-6-4

[6]
Diffusion MRI with Machine Learning.

Imaging Neurosci (Camb). 2024

[7]
TractCloud-FOV: Deep Learning-Based Robust Tractography Parcellation in Diffusion MRI With Incomplete Field of View.

Hum Brain Mapp. 2025-4-1

[8]
Tractography-Based Automated Identification of Retinogeniculate Visual Pathway With Novel Microstructure-Informed Supervised Contrastive Learning.

Hum Brain Mapp. 2024-12-1

[9]
Multimodal Neuroimaging Computing: Basics and Applications in Neurosurgery.

Adv Exp Med Biol. 2024

[10]
Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study.

J Headache Pain. 2024-11-4

本文引用的文献

[1]
Deep fiber clustering: Anatomically informed fiber clustering with self-supervised deep learning for fast and effective tractography parcellation.

Neuroimage. 2023-6

[2]
Short superficial white matter and aging: a longitudinal multi-site study of 1293 subjects and 2711 sessions.

Aging Brain. 2023

[3]
Superficial white matter bundle atlas based on hierarchical fiber clustering over probabilistic tractography data.

Neuroimage. 2022-11-15

[4]
The Developing Human Connectome Project Neonatal Data Release.

Front Neurosci. 2022-5-23

[5]
A transfer learning approach to few-shot segmentation of novel white matter tracts.

Med Image Anal. 2022-7

[6]
White matter myelination during early infancy is linked to spatial gradients and myelin content at birth.

Nat Commun. 2022-2-22

[7]
Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: A review.

Neuroimage. 2022-4-1

[8]
Deep Diffusion MRI Registration (DDMReg): A Deep Learning Method for Diffusion MRI Registration.

IEEE Trans Med Imaging. 2022-6

[9]
DeepBundle: Fiber Bundle Parcellation with Graph Convolution Neural Networks.

Graph Learn Med Imaging (2019). 2019

[10]
Volumetric white matter tract segmentation with nested self-supervised learning using sequential pretext tasks.

Med Image Anal. 2021-8

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