Zhang Heng-Chang, Du Yang, Chen Lei, Yuan Zeng-Qiang, Cheng Yong
Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China.
Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Minzu University of China, Beijing, China.
Neurosci Biobehav Rev. 2023 Mar;146:105064. doi: 10.1016/j.neubiorev.2023.105064. Epub 2023 Jan 24.
The three sets of symptoms associated with schizophrenia-positive, negative, and cognitive-are burdensome and have serious effects on public health, which affects up to 1% of the population. It is now commonly believed that in addition to the traditional dopaminergic mesolimbic pathway, the etiology of schizophrenia also includes neuronal networks, such as glutamate, GABA, serotonin, BDNF, oxidative stress, inflammation and the immune system. Small noncoding RNA molecules called microRNAs (miRNAs) have come to light as possible participants in the pathophysiology of schizophrenia in recent years by having an impact on these systems. These small RNAs regulate the stability and translation of hundreds of target transcripts, which has an impact on the entire gene network. There may be improved approaches to treat and diagnose schizophrenia if it is understood how these changes in miRNAs alter the critical related signaling pathways that drive the development and progression of the illness.
与精神分裂症相关的三组症状——阳性、阴性和认知症状——负担沉重，对公共卫生有严重影响，精神分裂症影响着高达1%的人口。现在普遍认为，除了传统的多巴胺能中脑边缘通路外，精神分裂症的病因还包括神经网络，如谷氨酸、γ-氨基丁酸、血清素、脑源性神经营养因子、氧化应激、炎症和免疫系统。近年来，一种名为微小RNA（miRNA）的小非编码RNA分子作为精神分裂症病理生理学的可能参与者而受到关注，因为它们会影响这些系统。这些小RNA调节数百种靶转录本的稳定性和翻译，从而影响整个基因网络。如果能够了解miRNA的这些变化如何改变驱动该疾病发生和发展的关键相关信号通路，那么可能会有更好的精神分裂症治疗和诊断方法。
