Zaki Mohamed Bakr, Abulsoud Ahmed I, Ashraf Alaa, Abdelmaksoud Nourhan M, Sallam Al-Aliaa M, Aly Shaza H, Sa'eed El-Tokhy Fatma, Rashad Ahmed A, El-Dakroury Walaa A, Abdel Mageed Sherif S, Nomier Yousra, Elrebehy Mahmoud A, Elshaer Shereen Saeid, Elballal Mohammed S, Mohammed Osama A, Abdel-Reheim Mustafa Ahmed, Doghish Ahmed S
Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Menoufia 32897, Egypt.
Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
Pathol Res Pract. 2024 Feb;254:155102. doi: 10.1016/j.prp.2024.155102. Epub 2024 Jan 9.
microRNAs (miRNAs) play a crucial role in brain growth and function. Hence, research on miRNA has the potential to reveal much about the etiology of neuropsychiatric diseases. Among these, schizophrenia (SZ) is a highly intricate and destructive neuropsychiatric ailment that has been thoroughly researched in the field of miRNA. Despite being a relatively recent area of study about miRNAs and SZ, this discipline has advanced enough to justify numerous reviews that summarize the findings from the past to the present. However, most reviews cannot cover all research, thus it is necessary to synthesize the large range of publications on this topic systematically and understandably. Consequently, this review aimed to provide evidence that miRNAs play a role in the pathophysiology and progression of SZ. They have also been investigated for their potential use as biomarkers and therapeutic targets.
微小RNA（miRNA）在大脑发育和功能中起着至关重要的作用。因此，对miRNA的研究有可能揭示许多神经精神疾病的病因。其中，精神分裂症（SZ）是一种高度复杂且具有破坏性的神经精神疾病，在miRNA领域已经进行了深入研究。尽管这是一个关于miRNA和SZ的相对较新的研究领域，但该学科已经取得了足够的进展，足以支持众多总结从过去到现在研究结果的综述。然而，大多数综述无法涵盖所有研究，因此有必要系统且易懂地综合关于该主题的大量出版物。因此，本综述旨在提供证据证明miRNA在SZ的病理生理学和进展中发挥作用。它们还被研究作为生物标志物和治疗靶点的潜在用途。
