Al-Noaman Ahmed, Rawlinson Simon Charles Fielding
Department of Oral Surgery, College of Dentistry, University of Babylon, Babylon City, Iraq.
School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Eur J Oral Sci. 2023 Apr;131(2):e12915. doi: 10.1111/eos.12915. Epub 2023 Jan 27.
Polyether ether ketone (PEEK) is a biocompatible material that lacks antimicrobial activity and bioactivity; therefore, is not appropriate for use as a dental implant. To overcome these deficiencies, a novel composite coating of bioactive glass and graphene oxide was prepared. PEEK discs were polished, cleaned, and the surface treated with sulfuric acid for 15 min. The composite coating consisted of bioactive glass produced by the sol-gel route and doped with 0.75 wt% graphene oxide. X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy-energy dispersive spectroscopy analyses were employed to characterize the composite coating, and the coating adhesion strength quantified using a pull-off test. Cytotoxicity was assessed using osteoblast-like cells and gingival fibroblasts. The wettability of the coated and non-coated samples was determined by optical contact angle assessment, and bioactivity was assessed by immersion in simulated body fluid. The results revealed that the bioactive glass/graphene oxide composite coating, approximately 7 μm thick, was transparent, homogenous with few microcracks and microporosities, but adhered strongly and was not cytotoxic to either osteoblast-like cells or gingival fibroblasts. The wettability of the PEEK sample was increased to <20° after coating with the composite, and apatite formation was detectable after 14 days of immersion in simulated body fluid.
聚醚醚酮（PEEK）是一种生物相容性材料，但缺乏抗菌活性和生物活性，因此不适用于牙科植入物。为了克服这些缺陷，制备了一种新型的生物活性玻璃和氧化石墨烯复合涂层。对PEEK圆盘进行抛光、清洁，并用硫酸对其表面处理15分钟。该复合涂层由通过溶胶-凝胶法制备并掺杂0.75 wt%氧化石墨烯的生物活性玻璃组成。采用X射线衍射、傅里叶变换红外光谱和扫描电子显微镜-能量色散光谱分析对复合涂层进行表征，并使用拉伸试验对涂层附着力强度进行量化。使用成骨样细胞和牙龈成纤维细胞评估细胞毒性。通过光学接触角评估确定涂覆和未涂覆样品的润湿性，并通过浸入模拟体液中来评估生物活性。结果表明，约7μm厚的生物活性玻璃/氧化石墨烯复合涂层是透明的、均匀的，几乎没有微裂纹和微孔，但附着力强，对成骨样细胞或牙龈成纤维细胞均无细胞毒性。用该复合材料涂覆后，PEEK样品的润湿性增加到<20°，在浸入模拟体液14天后可检测到磷灰石形成。
