University of Babylon, College of Dentistry, Department of Oral Surgery, Babylon City, Iraq.
Queen Mary University of London, School of Medicine and Dentistry, London, UK.
Dent Mater. 2024 Nov;40(11):e72-e81. doi: 10.1016/j.dental.2024.07.007. Epub 2024 Aug 8.
Dental implants fabricated from titanium have several limitations and therefore, alternative materials that fulfil the criteria of successful dental implant (bioactivity and anti-bacterial activity) need to be considered. Polyether ether ketone (PEEK) has been suggested to replace titanium implants. However, this material needs surface modification to meet the appropriate criteria. A nano-sized zirconium phosphate/GO (nZrP/GO) composite coating was prepared to improve PEEK's biological qualities.
Polished and cleaned PEEK discs were coated with the composite of nZrP doped with 1.25 wt% GO by the soft-template method. To analyze the composite coating, X-ray, atomic force microscopy, and field emission scanning electron microscopy-energy dispersive spectroscopy were used. The adhesion of the coating to PEEK was measured by adhesive tape test. By measuring the optical contact angle, the coated and non-coated samples' differences in wettability were evaluated. Antimicrobial activity was evaluated against S. aureus and E. coli and cytotoxicity tested employing gingival fibroblasts and osteoblast-like cells.
The nZrP/GO composite coating was 23.45 µm thick, was irregular and attached strongly to the PEEK surface. Following coating, the water contact angle dropped to 34° and surface roughness to 13 nm. The coating reduced the count of bacteria two-fold and was non-cytotoxic to mammalian osteoblast-like cells and fibroblasts. A precipitation of nano-calcium-deficient apatite was observed on the surface of the nZrP/GO coating following a 28-day immersion in SBF.
PEEK-coated with nZr/GO coating is a good candidate as dental implant.
钛制牙种植体存在一些局限性，因此需要考虑替代材料来满足成功牙种植体的标准（生物活性和抗菌活性）。聚醚醚酮（PEEK）已被提议替代钛植入物。然而，这种材料需要表面改性以满足适当的标准。制备了纳米尺寸的磷酸锆/GO（nZrP/GO）复合涂层来改善 PEEK 的生物特性。
通过软模板法在抛光和清洁的 PEEK 圆盘上涂覆掺杂有 1.25wt%GO 的纳米 ZrP 复合材料。使用 X 射线、原子力显微镜和场发射扫描电子显微镜-能谱分析来分析复合涂层。通过胶带试验测量涂层对 PEEK 的附着力。通过测量光学接触角来评估涂层和未涂层样品在润湿性方面的差异。评估了对金黄色葡萄球菌和大肠杆菌的抗菌活性，并采用牙龈成纤维细胞和成骨样细胞测试了细胞毒性。
nZrP/GO 复合涂层厚 23.45µm，不规则且牢固地附着在 PEEK 表面。涂层后，水接触角降至 34°，表面粗糙度降至 13nm。涂层将细菌数量减少了一倍，对哺乳动物成骨样细胞和成纤维细胞无细胞毒性。在 SBF 浸泡 28 天后，在 nZrP/GO 涂层表面观察到纳米缺钙磷灰石的沉淀。
涂有 nZr/GO 涂层的 PEEK 是一种有前途的牙科植入物候选材料。
