Department of Obstetrics, Gynecology and Reproductive Medicine, Dexeus University Hospital, 08028 Barcelona, Spain; IVI-RMA Lisboa, Portugal; Autonomous University of Barcelona, 08193, Cerdanyola del Vallès, Barcelona, Spain.
Conceptum - Unidad de Fertilidad del Country. 110221 Bogotá, Colombia.
Best Pract Res Clin Obstet Gynaecol. 2023 Mar;87:102307. doi: 10.1016/j.bpobgyn.2022.102307. Epub 2022 Dec 27.
The available literature is controversial regarding the association between the number of oocytes retrieved and the cumulative live birth rate (CLBR). Although some authors report a continuous increase in the CLBR with the number of oocytes retrieved, others have found a plateau. A systematic review was conducted, including all eligible studies published until June 2022, to determine the optimal number of oocytes retrieved to maximize the CLBR. We found a positive association between the number of oocytes and the CLBR. However, this association varies according to patients' age. While in patients younger than 35 years, little benefit is derived from increasing the number of oocytes above 25-30, in patients older than 35 years, the number of oocytes seems to improve the CLBR until the extreme of reproductive age is reached. In women aged 44 years or older, the CLBR will be consistently low, independent of the number of oocytes retrieved.
现有文献对于获卵数与累积活产率（CLBR）之间的关系存在争议。虽然一些作者报告说 CLBR 随着获卵数的增加而持续增加，但也有作者发现了一个平台期。进行了一项系统评价，包括截至 2022 年 6 月发表的所有合格研究，以确定获得最佳获卵数以最大限度提高 CLBR。我们发现获卵数与 CLBR 之间存在正相关关系。然而，这种关联因患者年龄而异。虽然在年龄小于 35 岁的患者中，从增加 25-30 个以上的获卵数中获益甚微，但在年龄大于 35 岁的患者中，获卵数似乎可以提高 CLBR，直到达到生育年龄的极限。在 44 岁或以上的女性中，无论获卵数多少，CLBR 都会持续较低。
