Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR 72205, USA.
Planta Med. 2012 Sep;78(13):1490-514. doi: 10.1055/s-0031-1298331. Epub 2012 May 7.
In Part 2 of this review, a critical examination of the pertinent scientific literature is undertaken in order to assess the interaction risk that popular dietary supplements may pose when taken concomitantly with conventional medications. Botanicals most likely to produce clinically important herb-drug interactions are those whose phytochemicals act as mechanism-based inhibitors of cytochrome P450 enzyme activity (e.g., Hydrastis canadensis, Piper nigrum, Schisandra chinensis) or function as ligands for orphan nuclear receptors (e.g., Hypericum perforatum). In addition, several external factors unrelated to phytochemical pharmacology can augment the drug interaction potential of botanical supplements.
在这篇综述的第二部分中，我们对相关科学文献进行了批判性地评估，以评估当常用药物与流行的膳食补充剂同时服用时可能产生的相互作用风险。最有可能产生临床重要的草药-药物相互作用的植物药是那些其植物化学物质作为细胞色素 P450 酶活性的基于机制的抑制剂（例如，加拿大升麻、胡椒、五味子）或作为孤儿核受体的配体（例如贯叶金丝桃）的植物药。此外，与植物化学药理学无关的几个外部因素可以增强植物补充剂的药物相互作用潜力。
