Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Microbiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Bioinformatics. 2023 Feb 3;39(2). doi: 10.1093/bioinformatics/btad061.
We recently introduced the Gut Microbiome Wellness Index (GMWI), a stool metagenome-based indicator for assessing health by determining the likelihood of disease given the state of one's gut microbiome. The calculation of our wellness index depends on the relative abundances of health-prevalent and health-scarce species. Encouragingly, GMWI has already been utilized in various studies focusing on differences in the gut microbiome between cases and controls. Herein, we introduce the GMWI-webtool, a user-friendly browser application that computes GMWI, health-prevalent/-scarce species' relative abundances, and α-diversities from stool shotgun metagenome taxonomic profiles. Users of our interactive online tool can visualize their results and compare them side-by-side with those from our pooled reference dataset of metagenomes, as well as export data in.csv format and high-resolution figures.
GMWI-webtool is freely available here: https://gmwi-webtool.github.io/.
Supplementary data are available at Bioinformatics online.
我们最近引入了肠道微生物组健康指数（Gut Microbiome Wellness Index，GMWI），这是一种基于粪便宏基因组的指标，通过确定一个人的肠道微生物组的状态来评估健康的可能性。我们的健康指数的计算取决于健康流行和健康稀缺物种的相对丰度。令人鼓舞的是，GMWI 已经在各种研究中被用于研究病例和对照组之间的肠道微生物组差异。在这里，我们介绍了 GMWI-webtool，这是一个用户友好的浏览器应用程序，可从粪便鸟枪法宏基因组分类学图谱中计算 GMWI、健康流行/稀缺物种的相对丰度和α多样性。我们交互式在线工具的用户可以可视化他们的结果，并将其与我们的宏基因组 pooled 参考数据集的结果并排比较，还可以以.csv 格式和高分辨率的图形导出数据。
GMWI-webtool 可在此处免费获得：https://gmwi-webtool.github.io/。
补充数据可在生物信息学在线获得。
