Mellstedt H, Pettersson D, Holm G
Acta Med Scand. 1978;204(6):485-9. doi: 10.1111/j.0954-6820.1978.tb08477.x.
The blood lymphocytosis in CLL is caused mainly by a rise of immunoglobulin (Ig)-bearing leukemic lymphocytes. Most cells carry Fc-receptors, while the percentage with receptors for human complement is very low with the present technique. The leukemic lymphocytes carry only one of the light chain types, which suggests a monoclonal origin. CLL patients with lymphocytes expressing kappa light chains may have a more benign disease than lambda-CLL. T-lymphocyte levels are high during the early course of the disease but decrease with its progression and are low in patients with "active" disease.
慢性淋巴细胞白血病（CLL）中的血液淋巴细胞增多主要由携带免疫球蛋白（Ig）的白血病淋巴细胞增多引起。大多数细胞携带Fc受体，而采用目前技术检测到的具有人补体受体的细胞百分比非常低。白血病淋巴细胞仅携带一种轻链类型，这提示其起源为单克隆性。表达κ轻链的淋巴细胞性CLL患者的病情可能比λ-CLL患者更为良性。疾病早期T淋巴细胞水平较高，但随着疾病进展而降低，在“活动性”疾病患者中水平较低。
