School of Health Sciences, Faculty of Medicine and Health, International Medical University, 57000 Kuala Lumpur, Malaysia.
School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, 47500 Subang Jaya, Malaysia.
Asian Pac J Cancer Prev. 2023 Jan 1;24(1):37-47. doi: 10.31557/APJCP.2023.24.1.37.
Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summarises the findings from various articles on the mechanism, treatment outcomes, and overall effectiveness of H2 therapy on cancer management.
Using Cochrane, PubMed, and Google Scholar as the search engines, full-text articles in the scope of the study, written in English and within 10 years of publication were selected.
Out of the 677 articles, 27 articles fulfilled the eligibility criteria, where data was compiled into a table, outlining the general characteristics and findings. Throughout the different forms of H2 administration, study design and types of cancers reported, outcomes were found to be consistent.
From our analysis, H2 plays a promising therapeutic role as an independent therapy as well as an adjuvant in combination therapy, resulting in an overall improvement in survivability, quality of life, blood parameters, and tumour reduction. Although more comprehensive research is needed, given the promising outcomes, H2 is worth considering for use as a complement to current cancer therapy.
癌症仍然是一个难以治愈的目标，目前的治疗方法在不引起严重副作用的情况下无法展现出恢复效果。分子氢（H2）已被报道为癌症治疗的一种有前途的辅助治疗方法，具有诱导抗增殖、抗氧化、促凋亡和抗肿瘤作用的能力。本综述总结了来自不同文章的关于 H2 治疗癌症管理的机制、治疗结果和总体效果的发现。
使用 Cochrane、PubMed 和 Google Scholar 作为搜索引擎，选择在研究范围内、用英文撰写且发表时间在 10 年内的全文文章。
在 677 篇文章中，有 27 篇文章符合入选标准，数据被汇编成一个表格，概述了一般特征和发现。在不同形式的 H2 给药、研究设计和报告的癌症类型中，结果是一致的。
从我们的分析来看，H2 作为一种独立的治疗方法以及联合治疗的辅助治疗方法具有很大的治疗潜力，导致生存率、生活质量、血液参数和肿瘤缩小的整体改善。尽管需要更全面的研究，但鉴于其良好的结果，H2 值得考虑作为当前癌症治疗的补充。
