Goyal Priya, Rajala Maitreyi S
School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
Mol Cell Biochem. 2023 Nov;478(11):2409-2418. doi: 10.1007/s11010-023-04669-4. Epub 2023 Jan 28.
Viral infection is a kind of cellular stress that leads to the changes in cellular metabolism. Many metabolic pathways in a host cell such as glycolysis, amino acid and nucleotide synthesis are altered following virus infection. Both oncogenic and non-oncogenic viruses depend on host cell glycolysis for their survival and pathogenesis. Recent studies have shown that the rate of glycolysis plays an important role in oncolysis as well by oncolytic therapeutic viruses. During infection, viral proteins interact with various cellular glycolytic enzymes, and this interaction enhances the catalytic framework of the enzymes subsequently the glycolytic rate of the cell. Increased activity of glycolytic enzymes following their interaction with viral proteins is vital for replication and to counteract the inhibition of glycolysis caused by immune response. In this review, the importance of host cell glycolysis and the modulation of glycolysis by various viruses such as oncogenic, non-oncogenic and oncolytic viruses are presented.
病毒感染是一种导致细胞代谢发生变化的细胞应激。病毒感染后，宿主细胞中的许多代谢途径，如糖酵解、氨基酸和核苷酸合成都会发生改变。致癌病毒和非致癌病毒都依赖宿主细胞的糖酵解来实现其存活和致病。最近的研究表明，糖酵解速率在溶瘤治疗性病毒的溶瘤过程中也起着重要作用。在感染过程中，病毒蛋白与各种细胞糖酵解酶相互作用，这种相互作用增强了酶的催化结构，进而提高了细胞的糖酵解速率。糖酵解酶与病毒蛋白相互作用后活性增加，对于病毒复制以及对抗免疫反应引起的糖酵解抑制至关重要。在这篇综述中，阐述了宿主细胞糖酵解的重要性以及各种病毒，如致癌病毒、非致癌病毒和溶瘤病毒对糖酵解的调节作用。
