Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
Sci Rep. 2023 Jan 28;13(1):1593. doi: 10.1038/s41598-023-28858-9.
Recently, wearing facemasks in public has been raised due to the coronavirus disease 2019 epidemic worldwide. However, the performance and effectiveness of many existing products have raised significant concerns among people and professionals. Therefore, greater attempts have been focused recently to increase the efficacy of these products scientifically and industrially. In this respect, doping or impregnating facemask fabrics with metallic substances or nanoparticles like silver nanoparticles has been proposed. So, in the present study, we aimed to sonochemically coat silver nanoparticles on the non-woven Spunbond substrates at different sonication times and concentrations to develop antibacterial and antiviral facemask. The coated substrates were characterized using Field Emission Scanning Electron Microscope, Energy Dispersive X-Ray, X-ray diffraction, and Thermogravimetry analysis. The amount of silver released from the coated substrates was measured by atomic absorption spectroscopy. The filtration efficiency, pressure drop, and electrical conductivity of the coated samples were also investigated. The antibacterial activity of fabrics was evaluated against Escherichia coli and Staphylococcus aureus. Cellular viability of samples assessed by MTT and brine shrimp lethality tests. The results revealed that the higher sonication times and precursor concentrations result in a higher and more stable coating, larger particle size, wider particle size distribution, and lower content of released silver. Coated fabrics also revealed enhanced filtration efficiency (against nanosize particles), desired pressure drop, and antibacterial activity without significant cytotoxicity toward HEK 293 cells and Artemia nauplii. As a result, the coated fabrics could find potential applications in the development of facemasks for protection against different pathogenic entities.
最近,由于全球 2019 年冠状病毒病,人们普遍开始在公共场合佩戴口罩。然而,许多现有产品的性能和效果引起了人们和专业人士的极大关注。因此,最近人们更加努力地试图从科学和工业上提高这些产品的功效。在这方面,有人提议在口罩织物中掺杂或浸渍金属物质或纳米颗粒,如银纳米颗粒。因此,在本研究中,我们旨在通过不同的超声时间和浓度在非织造纺粘基底上超声涂覆银纳米颗粒,以开发具有抗菌和抗病毒功能的口罩。使用场发射扫描电子显微镜、能量色散 X 射线、X 射线衍射和热重分析对涂覆的基底进行了表征。通过原子吸收光谱法测量从涂覆的基底释放的银量。还研究了涂层样品的过滤效率、压降和电导率。通过 MTT 和卤虫致死试验评估了织物对大肠杆菌和金黄色葡萄球菌的抗菌活性。结果表明,较高的超声时间和前体浓度导致更高且更稳定的涂层、更大的粒径、更宽的粒径分布和更低的释放银含量。涂覆的织物还显示出增强的过滤效率(针对纳米尺寸的颗粒)、所需的压降和抗菌活性,对 HEK 293 细胞和卤虫无明显细胞毒性。因此,涂覆的织物可能在开发用于保护免受不同病原体侵害的口罩方面具有潜在的应用。