Dept. of Chemical Engineering and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg Virginia 24061, United States.
School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
ACS Appl Mater Interfaces. 2021 Feb 10;13(5):5919-5928. doi: 10.1021/acsami.0c19465. Epub 2021 Jan 22.
The ongoing COVID-19 pandemic has created a need for coatings that reduce infection from SARS-CoV-2 via surfaces. Such a coating could be used on common touch surfaces (e.g., door handles and railings) to reduce both disease transmission and fear of touching objects. Herein, we describe the design, fabrication, and testing of a cupric oxide anti-SARS-CoV-2 coating. Rapid loss of infectivity is an important design criterion, so a porous hydrophilic coating was created to allow rapid infiltration of aqueous solutions into the coating where diffusion distances to the cupric oxide surface are short and the surface area is large. The coating was deposited onto glass from a dispersion of cuprous oxide in ethanol and then thermally treated at 700 °C for 2 h to produce a CuO coating that is ≈30 μm thick. The heat treatment oxidized the cuprous oxide to cupric oxide and sintered the particles into a robust film. The SARS-CoV-2 infectivity from the CuO film was reduced by 99.8% in 30 min and 99.9% in 1 h compared to that from glass. The coating remained hydrophilic for at least 5 months, and there was no significant change in the cross-hatch test of robustness after exposure to 70% ethanol or 3 wt % bleach.
持续的 COVID-19 大流行催生了对涂层的需求，这种涂层可以通过表面减少 SARS-CoV-2 的感染。这种涂层可以用在常见的触摸表面（如门把手和栏杆）上，以减少疾病的传播和对触摸物体的恐惧。本文描述了氧化铜抗 SARS-CoV-2 涂层的设计、制备和测试。快速丧失感染力是一个重要的设计标准，因此，我们制备了一种多孔亲水涂层，以允许水溶液快速渗透到涂层中，在那里扩散到氧化铜表面的距离较短，表面积较大。该涂层由氧化铜在乙醇中的分散体在玻璃上沉积，然后在 700°C 下热处理 2 小时，以产生约 30μm 厚的 CuO 涂层。热处理将氧化亚铜氧化为氧化铜，并将颗粒烧结成坚固的薄膜。与玻璃相比，CuO 薄膜在 30 分钟内将 SARS-CoV-2 的感染力降低了 99.8%，在 1 小时内降低了 99.9%。该涂层至少保持亲水性 5 个月，并且在暴露于 70%乙醇或 3wt%漂白剂后，其十字交叉测试的坚固性没有明显变化。
