Sheynikhovich Denis, Otani Satoru, Bai Jing, Arleo Angelo
Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.
Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Paris, France.
Front Behav Neurosci. 2023 Jan 11;16:1068271. doi: 10.3389/fnbeh.2022.1068271. eCollection 2022.
Mnemonic functions, supporting rodent behavior in complex tasks, include both long-term and (short-term) working memory components. While working memory is thought to rely on persistent activity states in an active neural network, long-term memory and synaptic plasticity contribute to the formation of the underlying synaptic structure, determining the range of possible states. Whereas, the implication of working memory in executive functions, mediated by the prefrontal cortex (PFC) in primates and rodents, has been extensively studied, the contribution of long-term memory component to these tasks received little attention. This review summarizes available experimental data and theoretical work concerning cellular mechanisms of synaptic plasticity in the medial region of rodent PFC and the link between plasticity, memory and behavior in PFC-dependent tasks. A special attention is devoted to unique properties of dopaminergic modulation of prefrontal synaptic plasticity and its contribution to executive functions.
助记功能支持啮齿动物在复杂任务中的行为，包括长期和（短期）工作记忆成分。虽然工作记忆被认为依赖于活跃神经网络中的持续活动状态，但长期记忆和突触可塑性有助于形成潜在的突触结构，决定可能状态的范围。然而，灵长类和啮齿动物中由前额叶皮层（PFC）介导的工作记忆在执行功能中的作用已得到广泛研究，而长期记忆成分对这些任务的贡献却很少受到关注。本综述总结了关于啮齿动物PFC内侧区域突触可塑性的细胞机制以及PFC依赖性任务中可塑性、记忆和行为之间联系的现有实验数据和理论工作。特别关注了前额叶突触可塑性多巴胺能调节的独特特性及其对执行功能的贡献。
