Liu Jing, Song Shuang, Gu Xiaoya, Li Hui, Yu Xiaobing
Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Graduate School of Peking Union Medical College, Beijing, China.
Front Neurosci. 2023 Jan 13;16:1121899. doi: 10.3389/fnins.2022.1121899. eCollection 2022.
A systematic review and meta-analysis was conducted to investigate changes in retinal and choroidal microvasculature in patients with multiple sclerosis (MS) using optical coherence tomography angiography (OCTA).
PubMed and Google Scholar were searched for studies that compared retinal and choroidal microvasculature between MS and healthy controls (HC) with OCTA. MS patients were divided into 2 groups: MS with (MSON) or without optic neuritis (MSNON).
Totally, 13 studies including 996 MS eyes and 847 HC eyes were included. Compared with the HC, the vessel density of the whole superficial vascular complex (SVC) was reduced by 2.27% and 4.30% in the MSNON and MSON groups, respectively. The peripapillary vessel density was 2.28% lower and 4.96% lower in the MSNON and MSON groups, respectively, than in the HC. Furthermore, the MSON group had significant lower vessel density of the SVC (mean difference [MD] = -2.17%, < 0.01) and lower peripapillary vessel density (MD = -2.02%, = 0.02) than the MSNON group. No significant difference was found in the deep vascular complex or choriocapillaris densities among MSNON, MSON or HC groups ( > 0.05). Meta-regression analyses suggested that illness duration and the Expanded Disability Status Scale scores of MS patients were possible sources of heterogeneity ( < 0.05).
The retinal SVC and peripapillary vessel density decreased significantly in MS eyes, especially in eyes with optic neuritis. Retinal microvasculature is a potential biomarker of disease progression in MS.
进行一项系统评价和荟萃分析，以利用光学相干断层扫描血管造影（OCTA）研究多发性硬化症（MS）患者视网膜和脉络膜微血管的变化。
在PubMed和谷歌学术上搜索使用OCTA比较MS患者与健康对照（HC）之间视网膜和脉络膜微血管的研究。MS患者分为两组：患有视神经炎的MS（MSON）和未患有视神经炎的MS（MSNON）。
总共纳入了13项研究，包括996只MS患者眼和847只HC眼。与HC相比，MSNON组和MSON组整个浅表血管复合体（SVC）的血管密度分别降低了2.27%和4.30%。MSNON组和MSON组视乳头周围血管密度分别比HC组低2.28%和4.96%。此外，MSON组的SVC血管密度（平均差[MD]=-2.17%，<0.01）和视乳头周围血管密度（MD=-2.02%，=0.02）显著低于MSNON组。在MSNON组、MSON组或HC组之间，深部血管复合体或脉络膜毛细血管密度未发现显著差异（>0.05）。荟萃回归分析表明，MS患者的病程和扩展残疾状态量表评分可能是异质性的来源（<0.05）。
MS患者眼中视网膜SVC和视乳头周围血管密度显著降低，尤其是在患有视神经炎的眼中。视网膜微血管是MS疾病进展的潜在生物标志物。
