Wu Min, Huang Yuxin, Huang Xiaoyu, Wang Fu, Wei Xunbin
Department of Plastic and Reconstructive Surgery, School of Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Front Chem. 2023 Jan 13;11:1124559. doi: 10.3389/fchem.2023.1124559. eCollection 2023.
Nanotheranostic agents that integrate diagnosis and treatment are promising for precision medicine, but they encounter some obstacles such as penetration depth and efficiency. In this study, novel carbon nitride-rose bengal nanoparticles (CN-RB NPs) with a graphite carbon nitride skeleton were synthesized by one-step thermal copolymerization. The enhanced absorption in the near-infrared-II region (NIR-II) endows CN-RB NPs with an excellent photothermal effect under 1064 nm laser irradiation, as well as an obvious photoacoustic signal for imaging . Interestingly, due to the introduced iodine element, CN-RB NPs exhibit enhanced radiation therapy, indicating that CN-RB NPs can achieve ideal therapeutic outcome through collaborative photothermal/radiation therapy under the guidance of NIR-II photoacoustic imaging. Moreover, CN-RB NPs demonstrate minimal side effects and long-term biological stability after 14 days. Therefore, the proposed new multifunctional nano-platform CN-RB NPs hold great potential in the application of deep therapeutics.
将诊断与治疗相结合的纳米诊疗剂在精准医学方面很有前景，但它们面临着一些障碍，如穿透深度和效率。在本研究中，通过一步热共聚合成了具有石墨相氮化碳骨架的新型氮化碳-孟加拉玫瑰红纳米颗粒（CN-RB NPs）。在近红外二区（NIR-II）的增强吸收赋予CN-RB NPs在1064 nm激光照射下优异的光热效应，以及用于成像的明显光声信号。有趣的是，由于引入了碘元素，CN-RB NPs表现出增强的放射治疗效果，这表明CN-RB NPs可以在NIR-II光声成像的引导下通过协同光热/放射治疗实现理想的治疗效果。此外，CN-RB NPs在14天后显示出最小的副作用和长期的生物稳定性。因此，所提出的新型多功能纳米平台CN-RB NPs在深部治疗应用中具有巨大潜力。
