生活在贝宁同域分布的富拉尼族、巴里巴族、奥塔马里族和甘多族个体对疟疾的易感性：抗恶性疟原虫子孢子调理素抗体的作用。
Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites.
作者信息
Fall Abdou Khadre Dit Jadir, Kana Ikhlaq Hussain, Garcia-Senosiain Asier, Henry Benoît, Dechavanne Célia, Garcia André, Buffet Pierre, Sabbagh Audrey, Migot-Nabias Florence, Theisen Michael, Courtin David
机构信息
Université Paris Cité, IRD, UMR261, MERIT, F-75006 Paris, France.
Department for Congenital Disorders, Statens Serum Institut, Denmark.
出版信息
Heliyon. 2023 Jan 20;9(1):e13092. doi: 10.1016/j.heliyon.2023.e13092. eCollection 2023 Jan.
OBJECTIVES
Fulani in Africa are known to be less susceptible to () malaria. This study explored a potential involvement of antibody-mediated merozoite phagocytosis mechanism in this natural protection against malaria.
METHODS
Before the start of the malaria transmission season (MTS) in Benin, the functionality of antibodies against merozoites was determined by the opsonic phagocytosis (OP) assay in plasma samples from Fulani, Bariba, Otamari and Gando groups. These individuals were actively followed-up for malaria detection from the beginning to the end of MTS. -GLURP Immunoglobulin G antibody quantification, malaria Rapid Diagnostic Test (RDT) and spleen palpation were performed before and after MTS.
RESULTS
In Bariba, Otamari and Gando, but not in Fulani, plasma from adults promoted higher levels of OP than the children (P = 0.003; P = 0.012; P = 0.031 and P = 0.122). A high proportion of Fulani children had higher OP and -GLURP (P < 0.0001) antibody levels as compared to non-Fulani children; whereas this was not observed for Fulani adults (P = 0.223). High OP levels before MTS were significantly related to negative RDT after MTS (P = 0.011).
CONCLUSION
Our results highlight the ability of opsonizing antibodies to potentially enhance natural protection of young Fulani individuals against Pf malaria in Benin.
目的
众所周知，非洲的富拉尼人对（）疟疾的易感性较低。本研究探讨了抗体介导的裂殖子吞噬机制在这种针对疟疾的天然保护中的潜在作用。
方法
在贝宁疟疾传播季节（MTS）开始前，通过调理吞噬作用（OP）试验，对富拉尼、巴里巴、奥塔马里和甘多族人群血浆样本中抗裂殖子抗体的功能进行了测定。从MTS开始到结束，对这些个体进行了积极的疟疾检测随访。在MTS前后进行了-GLURP免疫球蛋白G抗体定量、疟疾快速诊断试验（RDT）和脾脏触诊。
结果
在巴里巴、奥塔马里和甘多族人群中，而非富拉尼族人群中，成人血浆比儿童血浆促进了更高水平的OP（P = 0.003；P = 0.012；P = 0.031和P = 0.122）。与非富拉尼族儿童相比，高比例的富拉尼族儿童具有更高的OP和-GLURP（P < 0.0001）抗体水平；而富拉尼族成人未观察到这种情况（P = 0.223）。MTS前的高OP水平与MTS后的RDT阴性显著相关（P = 0.011）。
结论
我们的结果突出了调理抗体在增强贝宁年轻富拉尼个体对恶性疟原虫疟疾的天然保护方面的潜在能力。
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