Dechavanne Célia, Sadissou Ibrahim, Bouraima Aziz, Ahouangninou Claude, Amoussa Roukiyath, Milet Jacqueline, Moutairou Kabirou, Massougbodji Achille, Theisen Michael, Remarque Edmond J, Courtin David, Nuel Gregory, Migot-Nabias Florence, Garcia André
Institut de Recherche pour le Développement, UMR 216 Mère et enfant face aux infections tropicales, Paris, France.
COMUE Sorbonne Paris Cité, Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
Sci Rep. 2016 Sep 27;6:33961. doi: 10.1038/srep33961.
To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.
据我们所知，在一项针对生活在疟疾流行地区的婴儿疟疾抗体反应获得情况的研究中，从未同时探讨过年龄、胎盘疟疾感染、随访期间的感染、营养习惯、镰状细胞性状以及个体被按蚊叮咬情况的影响。567名贝宁婴儿从出生到18个月龄每周接受随访。每3个月测量一次针对5种疟疾抗原的免疫球蛋白G（IgG）、IgG1和IgG3。在单变量和多变量分析中，使用线性混合模型分析每个变量对6至18个月龄婴儿抗疟疾抗体获得情况的影响。胎盘疟疾、营养摄入和镰状细胞性状并未影响婴儿对恶性疟原虫抗原的抗体水平。相反，年龄、出生时的疟疾抗体水平、既往和当前的疟疾感染以及被按蚊叮咬情况与6至18个月龄贝宁婴儿疟疾抗体的自然获得显著相关。这项研究强调了在早期生活的免疫流行病学研究或疫苗试验中需要同时考虑的不可避免的因素。
