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晚期动脉粥样硬化昼夜节律调节关键基因的筛选：一项生物信息学分析

Screening for key genes in circadian regulation in advanced atherosclerosis: A bioinformatic analysis.

作者信息

Yao Jiali, Liang Jingyan, Li Hongliang

机构信息

Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China.

Jiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research, Yangzhou University, Yangzhou, Jiangsu, China.

出版信息

Front Cardiovasc Med. 2023 Jan 12;9:990757. doi: 10.3389/fcvm.2022.990757. eCollection 2022.

DOI:10.3389/fcvm.2022.990757
PMID:36712250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9878187/
Abstract

BACKGROUND

Atherosclerosis (AS) is the most important cardiovascular disease threatening human health, leading to adverse events such as myocardial infarction and stroke. The research on the pathogenesis and causes of AS is being improved step by step, and many factors are associated with AS. However, the relationship between circadian regulation and the pathogenesis of AS is still unclear. Our study identified 2 key genes of circadian regulation in AS by bioinformatics analysis, which provides new perspectives to understand the relationship between circadian rhythm and AS.

METHODS

We downloaded samples of early and advanced AS from public databases, screened key genes by weighted gene co-expression network analysis (WGCNA) and Lasso, calculated the immune cell content of the samples using "CIBERSORT," and analyzed the relationship between key genes and immune cells.

RESULTS

We obtained the most relevant core modules for advanced AS and analyzed the functions of these modules. Two circadian rhythm-related genes were obtained, which influence the immune infiltration of this late AS. ROC curves demonstrated the efficacy of key genes to differentiate between early and advanced AS.

CONCLUSION

We identified 2 genes most associated with circadian rhythms in advanced AS, whose association with AS has not been elucidated and may become the next therapeutic target.

摘要

背景

动脉粥样硬化（AS）是威胁人类健康的最重要的心血管疾病，可导致心肌梗死和中风等不良事件。对AS发病机制和病因的研究正在逐步完善，许多因素与AS相关。然而，昼夜节律调节与AS发病机制之间的关系仍不清楚。我们的研究通过生物信息学分析确定了AS中昼夜节律调节的2个关键基因，为理解昼夜节律与AS之间的关系提供了新的视角。

方法

我们从公共数据库下载了早期和晚期AS的样本，通过加权基因共表达网络分析（WGCNA）和套索回归筛选关键基因，使用“CIBERSORT”计算样本的免疫细胞含量，并分析关键基因与免疫细胞之间的关系。

结果

我们获得了与晚期AS最相关的核心模块，并分析了这些模块的功能。获得了2个与昼夜节律相关的基因，它们影响晚期AS的免疫浸润。ROC曲线证明了关键基因区分早期和晚期AS的有效性。

结论

我们确定了晚期AS中与昼夜节律最相关的2个基因，它们与AS的关联尚未阐明，可能成为下一个治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/4e2592a4c249/fcvm-09-990757-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/709e73e414f7/fcvm-09-990757-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/727e05482159/fcvm-09-990757-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/63809bcbd6e2/fcvm-09-990757-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/a9193a585862/fcvm-09-990757-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/3868c785e97a/fcvm-09-990757-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/1bd2339c465e/fcvm-09-990757-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/3fc659752e09/fcvm-09-990757-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/4e2592a4c249/fcvm-09-990757-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/709e73e414f7/fcvm-09-990757-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/727e05482159/fcvm-09-990757-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/63809bcbd6e2/fcvm-09-990757-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/a9193a585862/fcvm-09-990757-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/3868c785e97a/fcvm-09-990757-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/1bd2339c465e/fcvm-09-990757-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/3fc659752e09/fcvm-09-990757-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d8/9878187/4e2592a4c249/fcvm-09-990757-g008.jpg

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