Cunnane J G, Blackwood G W
Department of Psychiatry, St. James' University Hospital, Leeds, UK.
Postgrad Med J. 1987 Jan;63(735):57-8. doi: 10.1136/pgmj.63.735.57.
A 21 year old male developed hallucinations, personality change and severe depression following an increase in oral propranolol administration at recommended dosage levels. The symptoms improved markedly on stopping the drug. Without provocation, the patient developed further symptoms, mainly depressive, with marked suicidal impulses. Again, this quickly settled. The case identifies the need for careful observation of patients with psychiatric side effects from propranolol, following discontinuation of the drug.
一名21岁男性在按推荐剂量增加口服普萘洛尔后出现幻觉、人格改变和严重抑郁。停药后症状明显改善。在没有诱因的情况下，患者再次出现症状，主要是抑郁，并伴有明显的自杀冲动。症状再次迅速缓解。该病例表明，在停用普萘洛尔后，有必要对出现精神科副作用的患者进行仔细观察。
