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外周神经创伤性神经瘤:诊断、管理及未来展望

Traumatic neuromas of peripheral nerves: Diagnosis, management and future perspectives.

作者信息

Yang Hu, Dong Yanzhao, Wang Zewei, Lai Jingtian, Yao Chenjun, Zhou Haiying, Alhaskawi Ahmad, Hasan Abdullah Ezzi Sohaib, Kota Vishnu Goutham, Hasan Abdulla Hasan Abdulla Mohamed, Lu Hui

机构信息

Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.

Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

出版信息

Front Neurol. 2023 Jan 11;13:1039529. doi: 10.3389/fneur.2022.1039529. eCollection 2022.

Abstract

Traumatic neuromas are infrequent in clinical settings but are prevalent following trauma or surgery. A traumatic neuroma is not a true malignancy, rather, it is a hyperplastic, reparative nerve reaction after injury and typically manifests as a nodular mass. The most common clinical manifestations include painful hypersensitivity and the presence of a trigger point that causes neuralgic pain, which could seriously decrease the living standards of patients. While various studies are conducted aiming to improve current diagnosis and management strategies the induction of emerging imaging tools and surgical or conservative treatment. However, researchers and clinicians have yet to reach a consensus regarding traumatic neuromas. In this review, we aim to start with the possible underlying mechanisms of traumatic neuromas, elaborate on the diagnosis, treatment, and prevention schemes, and discuss the current experiment models and advances in research for the future management of traumatic neuromas.

摘要

创伤性神经瘤在临床环境中并不常见,但在创伤或手术后很普遍。创伤性神经瘤并非真正的恶性肿瘤,相反,它是损伤后的一种增生性、修复性神经反应,通常表现为结节状肿块。最常见的临床表现包括疼痛性超敏反应和导致神经痛的触发点的存在,这可能会严重降低患者的生活水平。虽然开展了各种研究以改进当前的诊断和管理策略,包括引入新兴的成像工具以及手术或保守治疗。然而,研究人员和临床医生对于创伤性神经瘤尚未达成共识。在本综述中,我们旨在从创伤性神经瘤可能的潜在机制入手,详细阐述诊断、治疗和预防方案,并讨论当前的实验模型以及未来创伤性神经瘤管理研究的进展。

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