Cao Xiang, Ren Yang, Lu Qinyue, Wang Kun, Wu Yanni, Wang YuHao, Zhang Yihui, Cui Xiang-Shun, Yang Zhangping, Chen Zhi
College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Department of Animal Science, Laboratory of Animal Developmental Biology, Chungbuk National University, Cheongju, Republic of Korea.
Front Nutr. 2023 Jan 5;9:1018336. doi: 10.3389/fnut.2022.1018336. eCollection 2022.
Lactoferrin (Lf), existing widely in human and mammalian milk, is a multifunctional glycoprotein with many functions, such as immune regulation, anti-inflammation, antibacterial, antiviral, and antioxidant. These extensive functions largely attribute to its ability to chelate iron and interfere with the cellular receptors of pathogenic microorganisms and their hosts. Moreover, it is non-toxic and has good compatibility with other supplements. Thus, Lf has been widely used in food nutrition, drug carriers, biotechnology, and feed development. Although Lf has been continuously explored and studied, a more comprehensive and systematic compendium is still required. This review presents the recent advances in the structure and physicochemical properties of Lf as well as clinical studies on human diseases, with the aim of providing a reference for further research of Lf and the development of its related functional products.
乳铁蛋白（Lf）广泛存在于人类和哺乳动物的乳汁中，是一种具有多种功能的多功能糖蛋白，如免疫调节、抗炎、抗菌、抗病毒和抗氧化等。这些广泛的功能很大程度上归因于其螯合铁以及干扰病原微生物及其宿主细胞受体的能力。此外，它无毒且与其他补充剂具有良好的相容性。因此，Lf已广泛应用于食品营养、药物载体、生物技术和饲料开发等领域。尽管对Lf的研究一直在不断探索，但仍需要更全面系统的综述。本文综述了Lf的结构、理化性质以及人类疾病临床研究的最新进展，旨在为Lf的进一步研究及其相关功能产品的开发提供参考。
