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作为异吲哚酮和2(3)-呋喃酮的插烯羟醛缩合反应双功能催化剂的β-二氨基磷酰基氨基硫脲的合成与评价

Synthesis and Evaluation of -Diaminophosphoryl Aminothioureas as Bifunctional Catalysts for Vinylogous Aldol Reactions of Isatins and 2(3)-Furanones.

作者信息

D V Hrishikesh, Annadate Ritesh A, Pansare Sunil V

机构信息

Department of Chemistry, Memorial University, St. John's, Newfoundland and Labrador, Canada A1B 3X7.

出版信息

ACS Omega. 2023 Jan 9;8(3):3190-3197. doi: 10.1021/acsomega.2c06637. eCollection 2023 Jan 24.

DOI:10.1021/acsomega.2c06637
PMID:36713689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9878653/
Abstract

The organocatalytic asymmetric direct vinylogous aldol reaction of -methylisatins and γ-butenolides to provide 3-hydroxy-2-oxindole derivatives was investigated. A series of -diaminophosphoryl aminothiourea catalysts was synthesized, and their utility for the stereoselective formation of was examined.

摘要

研究了α-甲基异吲哚酮与γ-丁烯内酯的有机催化不对称直接插烯羟醛反应，以制备3-羟基-2-吲哚酮衍生物。合成了一系列α-二氨基磷酰基氨基硫脲催化剂，并考察了它们在立体选择性形成该产物方面的效用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/72ef02d93023/ao2c06637_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/9489a0eb98eb/ao2c06637_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/8d4206bca47c/ao2c06637_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/2cdbc12f4b05/ao2c06637_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/774f2eeb4809/ao2c06637_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/804dfdbda689/ao2c06637_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/72ef02d93023/ao2c06637_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/aa0397c903f3/ao2c06637_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/fcf7e1075f8d/ao2c06637_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/9489a0eb98eb/ao2c06637_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/8d4206bca47c/ao2c06637_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/2cdbc12f4b05/ao2c06637_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/774f2eeb4809/ao2c06637_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/804dfdbda689/ao2c06637_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9c/9878653/72ef02d93023/ao2c06637_0008.jpg

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