作为异吲哚酮和2(3)-呋喃酮的插烯羟醛缩合反应双功能催化剂的β-二氨基磷酰基氨基硫脲的合成与评价
Synthesis and Evaluation of -Diaminophosphoryl Aminothioureas as Bifunctional Catalysts for Vinylogous Aldol Reactions of Isatins and 2(3)-Furanones.
作者信息
D V Hrishikesh, Annadate Ritesh A, Pansare Sunil V
机构信息
Department of Chemistry, Memorial University, St. John's, Newfoundland and Labrador, Canada A1B 3X7.
出版信息
ACS Omega. 2023 Jan 9;8(3):3190-3197. doi: 10.1021/acsomega.2c06637. eCollection 2023 Jan 24.
Abstract
The organocatalytic asymmetric direct vinylogous aldol reaction of -methylisatins and γ-butenolides to provide 3-hydroxy-2-oxindole derivatives was investigated. A series of -diaminophosphoryl aminothiourea catalysts was synthesized, and their utility for the stereoselective formation of was examined.
摘要
研究了α-甲基异吲哚酮与γ-丁烯内酯的有机催化不对称直接插烯羟醛反应，以制备3-羟基-2-吲哚酮衍生物。合成了一系列α-二氨基磷酰基氨基硫脲催化剂，并考察了它们在立体选择性形成该产物方面的效用。
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