Luthfianti Halida Rahmi, Waresindo William Xaveriano, Edikresnha Dhewa, Chahyadi Agus, Suciati Tri, Noor Fatimah Arofiati, Khairurrijal Khairurrijal
Doctoral Program of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha, 10, Bandung 40132, Jawa Barat, Indonesia.
Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha, 10, Bandung 40132, Jawa Barat, Indonesia.
ACS Omega. 2023 Jan 9;8(3):2915-2930. doi: 10.1021/acsomega.2c05110. eCollection 2023 Jan 24.
Andrographolide (AG) is one of the compounds in , which has a high antibacterial activity. This paper reports the freeze-thaw method's use to synthesize polyvinyl alcohol (PVA) hydrogels loaded with AG and its characterization. From the morphological examination, the porosity of the PVA/AG hydrogel was found to increase with the increasing AG concentration. The swelling degree test revealed that the hydrogels' maximum swelling degrees were generally greater than 100%. The composite hydrogel with the highest fraction of andrographolide (PAG-4) showed greater weight loss than the hydrogel without AG (PAG-0). The molecular interaction between PVA and AG resulted in the narrowing of the band attributed to the O-H and C=O stretching bonds and the emergence of an amorphous domain in the composite hydrogels. The loading of AG disrupted the formation of hydroxyl groups in PVA and interrupted the cross-linking between PVA chains, which lead to the decrease of the compression strength and the crystallinity increased with increasing AG. The antibacterial activity of the composite hydrogel increased with increasing AG. The PAG-4 hydrogel had the highest antibacterial activity of 37.9 ± 4.6 %. Therefore, the PVA/AG hydrogel has the potential to be used as an antibacterial device.
穿心莲内酯（AG）是其中一种具有高抗菌活性的化合物。本文报道了采用冻融法合成负载AG的聚乙烯醇（PVA）水凝胶及其表征。通过形态学检查发现，PVA/AG水凝胶的孔隙率随AG浓度的增加而增大。溶胀度测试表明，水凝胶的最大溶胀度一般大于100%。穿心莲内酯含量最高的复合水凝胶（PAG-4）比不含AG的水凝胶（PAG-0）表现出更大的重量损失。PVA与AG之间的分子相互作用导致归属于O-H和C=O伸缩键的谱带变窄，并且在复合水凝胶中出现了非晶区。AG的负载破坏了PVA中羟基的形成并中断了PVA链之间的交联，这导致抗压强度降低，且结晶度随AG增加而升高。复合水凝胶的抗菌活性随AG增加而增强。PAG-4水凝胶具有最高的抗菌活性，为37.9±4.6%。因此，PVA/AG水凝胶有潜力用作抗菌装置。
