一种用于骨组织工程的具有高机械强度、荧光和可降解性能的复合水凝胶。

A Composite Hydrogel with High Mechanical Strength, Fluorescence, and Degradable Behavior for Bone Tissue Engineering.

作者信息

Wang Yanqin, Xue Yanan, Wang Jinghui, Zhu Yaping, Zhu Yu, Zhang Xuehui, Liao Jingwen, Li Xiaona, Wu Xiaogang, Qin Yi-Xian, Chen Weiyi

机构信息

College of biomedical engineering, Taiyuan University of Technology, Taiyuan 030024, China.

State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.

出版信息

Polymers (Basel). 2019 Jul 1;11(7):1112. doi: 10.3390/polym11071112.

Abstract

In this work, to obtain a novel composite hydrogel with high mechanical strength, fluorescence and degradable behavior for bone tissue engineering, we prepare a nanofiller and double-network (DN) structure co-enhanced carbon dots/hydroxyapatite/poly (vinyl alcohol) (CDs/HA/PVA) DN hydrogel. The composite hydrogels are fabricated by a combination of two fabrication techniques including chemical copolymerization and freezing‒thawing cycles, and further characterized by FTIR, XRD, etc. Additional investigations focus on the mechanical properties of the hydrogel with varying mass ratios of CDs to PVA, HA to PVA and different numbers of freezing/thawing cycles. The results show that the as-prepared CDs/HA/PVA DN hydrogel has optimized compression properties (Compression strength = 3.462 MPa, Young's modulus = 4.5 kPa). This is mainly caused by the synergism effect of the nanofiller and chemical and physical co-crosslinking. The water content and swelling ratio of the CDs/HA/PVA SN and DN gels are also systematically investigated to reveal the relationship of their microstructural features and mechanical behavior. In addition, in vitro degradation tests of the CDs/HA/PVA DN hydrogel show that the DN hydrogels have a prominent degradable behavior. So, they have potential to be used as high-strength, self-tracing bone substitutes in the biomedical engineering field.

摘要

在本研究中,为了获得一种具有高机械强度、荧光性能和可降解性能的新型复合水凝胶用于骨组织工程,我们制备了一种纳米填料和双网络(DN)结构协同增强的碳点/羟基磷灰石/聚乙烯醇(CDs/HA/PVA)双网络水凝胶。该复合水凝胶通过化学共聚和冻融循环两种制备技术相结合的方法制备而成,并通过傅里叶变换红外光谱(FTIR)、X射线衍射(XRD)等进行进一步表征。另外的研究聚焦于具有不同CDs与PVA质量比、HA与PVA质量比以及不同冻融循环次数的水凝胶的力学性能。结果表明,所制备的CDs/HA/PVA双网络水凝胶具有优化的压缩性能(抗压强度 = 3.462 MPa,杨氏模量 = 4.5 kPa)。这主要是由纳米填料以及化学和物理共交联的协同效应导致的。还系统研究了CDs/HA/PVA单网络(SN)和双网络凝胶的含水量和溶胀率,以揭示它们微观结构特征与力学行为之间 的关系。此外,CDs/HA/PVA双网络水凝胶的体外降解试验表明,该双网络水凝胶具有显著的可降解性能。因此,它们有潜力在生物医学工程领域用作高强度、可自追踪的骨替代物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611c/6680580/0dafb783c8f9/polymers-11-01112-sch001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索