Moghaddas Omid, Naddafpour Nima, Farhadi Sareh, Nikookar Peyman, Khandan Sephora
Department of Periodontology, Faculty of Dentistry, Tehran Islamic Azad Medical Sciences University, Tehran, Iran.
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Islamic Azad Medical Sciences University, Tehran, Iran.
J Adv Periodontol Implant Dent. 2022 Oct 29;14(2):69-75. doi: 10.34172/japid.2022.020. eCollection 2022.
A decrease in the width and height of the alveolar ridge is inevitable following tooth extraction. This study aimed to histologically evaluate the amount of newly formed bone after using a freeze-dried bone allograft (FDBA) at two different intervals in the tooth socket grafting. Forty patients were selected, who required a single-rooted tooth extraction and were candidates for implant placement, with no indication for an immediate implant. Extraction sockets were preserved using a cortical FDBA allograft in two regeneration interval groups: 3 months (group A) and 4 months (group B). At the time of implant placement, a bone sample was collected from each grafted socket. Histomorphometric analyses were performed to determine the percentage of newly formed bone and the residual graft material. Changes in histological indices, i.e., inflammation rate, percentage of ossification, and the amount of remaining biomaterial, were evaluated. There were no significant differences in the amount of newly formed bone and residual graft material between the two groups. In general, the average of new bone formation and remaining graft particles in groups A and B was: %33.89 and %12.59 vs. %39.83 and %14.07, respectively. Bone parameters in group A were better compared to group B. However, due to the lack of significant differences in the results, it is suggested that implant placement in grafted sockets with mineralized allografts be expedited.
拔牙后牙槽嵴的宽度和高度减小是不可避免的。本研究旨在从组织学角度评估在牙槽窝植骨中于两个不同时间间隔使用冻干同种异体骨（FDBA）后新形成骨的量。选取了40例需要拔除单根牙且适合植入种植体、无即刻种植指征的患者。在两个再生间隔组中使用皮质FDBA同种异体骨保存拔牙窝：3个月（A组）和4个月（B组）。在植入种植体时，从每个植骨窝采集骨样本。进行组织形态计量分析以确定新形成骨的百分比和剩余移植材料。评估组织学指标的变化，即炎症率、骨化百分比和剩余生物材料的量。两组之间新形成骨的量和剩余移植材料无显著差异。总体而言，A组和B组新骨形成和剩余移植颗粒的平均值分别为：33.89%和12.59% 对比 39.83%和14.07%。A组的骨参数优于B组。然而，由于结果缺乏显著差异，建议加快在使用矿化同种异体骨的植骨窝中植入种植体。
