Department of Periodontics and Allied Dental Programs, Indiana University School of Dentistry, Indianapolis, IN 46202, USA.
J Periodontol. 2012 Jul;83(7):847-55. doi: 10.1902/jop.2011.110470. Epub 2011 Dec 13.
Many materials have been found to be effective in ridge preservation. The purpose of this study is to determine whether calcium sulfate (CS) is as effective as freeze-dried bone allograft (FDBA) in preserving postextraction ridge dimensions and to evaluate the amount of new bone formation and graft clearance through histologic analysis.
Thirty-one extraction sites were selected. Postextraction clinical measurements were made, and sites were divided randomly into the test group (CS) or the control group (FDBA). After graft placement, all individuals received the same postoperative treatment and instructions. Participants were recalled after 3 months, measurements were made, and sites were re-entered. Bone samples were harvested and analyzed with histologic methodology for new bone formation and remaining residual graft.
Thirteen test and 15 control sites were evaluated. There was no significant change in vertical ridge height before or after surgery within the test and control groups (P = 0.57, P = 0.68, respectively). There was a significant decrease in bucco-lingual ridge width for both groups (P = 0.0003, P = 0.0075, respectively), but the difference between groups was not significant (P = 0.11). Histologic analysis revealed an average of 32% new bone formation with 2.5% graft remaining for the test group and 16.7% new bone formation with 21% graft remaining for the control.
Results indicate that CS is as effective as FDBA in preserving postextraction ridge dimensions in non-molar extraction sites. There is greater clearance of CS with more new bone formation after ≈3 months compared with FDBA in these sites. This paper received the Maynard K. Hine Award for Excellence in Dental Research presented by the Indiana Section of the American Association for Dental Research and supported by Procter & Gamble.
许多材料已被证明在牙槽嵴保存方面有效。本研究旨在确定硫酸钙（CS）在保存拔牙后牙槽嵴尺寸方面是否与冻干骨同种异体移植物（FDBA）同样有效，并通过组织学分析评估新骨形成和移植物清除的量。
选择 31 个拔牙部位。拔牙后进行临床测量，并将部位随机分为实验组（CS）或对照组（FDBA）。放置移植物后，所有患者接受相同的术后治疗和指导。3 个月后召回患者，进行测量，并重新进入部位。采用组织学方法对新骨形成和剩余残留移植物进行骨样本采集和分析。
评估了 13 个测试部位和 15 个对照部位。实验组和对照组的垂直牙槽嵴高度在手术前后均无显著变化（P = 0.57，P = 0.68）。两组颊舌向牙槽嵴宽度均显著减小（P = 0.0003，P = 0.0075），但组间差异无统计学意义（P = 0.11）。组织学分析显示，实验组的新骨形成平均为 32%，剩余移植物为 2.5%，对照组的新骨形成平均为 16.7%，剩余移植物为 21%。
结果表明，CS 在保存非磨牙拔牙部位的拔牙后牙槽嵴尺寸方面与 FDBA 同样有效。在这些部位，CS 的清除率更高，在 ≈3 个月后有更多的新骨形成。本文获得了由美国牙科研究协会印第安纳州分部颁发的 Maynard K. Hine 牙科研究卓越奖，并得到了宝洁公司的支持。
