Koivula Tiia, Lempiäinen Salla, Rinne Petteri, Hollmén Maija, Sundberg Carl Johan, Rundqvist Helene, Minn Heikki, Heinonen Ilkka
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Institute of Biomedicine, University of Turku, Turku, Finland.
Front Physiol. 2023 Jan 11;13:1078512. doi: 10.3389/fphys.2022.1078512. eCollection 2022.
Studies have shown that acute exercise can mobilize several leukocyte subpopulations in healthy individuals. Our aim was to investigate whether a 10-min acute exercise has an effect on immune cell proportions in lymphoma patients. This study included seven lymphoma patients referred to curative oncologic therapy. Three had Hodgkin and four non-Hodgkin lymphoma, one was female, and their mean age was 51. Patients underwent a 10-min acute exercise on a bicycle ergometer at moderate exercise intensity. Whole blood samples were taken at rest, immediately after exercise, and 30 min after exercise. Leukocyte subpopulation levels were determined using flow cytometry. Proportions of total NK cells and CD56CD16 NK cells of total leukocytes increased immediately after exercise and decreased back to baseline at 30 min post-exercise. Proportion of CD8 T cells of total T cells increased and proportion of CD4 T cells of total T cells decreased immediately after exercise, and both returned to baseline at 30 min post-exercise. There was no change in the proportions of B cells, granulocytes, or monocytes. Exercising diastolic blood pressure correlated positively with changes in total NK cell and CD56CD16 NK cell proportions, and exercising mean arterial pressure correlated positively with change in CD56CD16 NK cell proportion. Our findings indicate that a single acute exercise bout of only 10 min can cause leukocytosis in lymphoma patients, particularly on cytotoxic T cells and NK cells, which are the most important immune cells fighting against cancer.
研究表明，急性运动可调动健康个体中的几种白细胞亚群。我们的目的是调查10分钟的急性运动是否会对淋巴瘤患者的免疫细胞比例产生影响。本研究纳入了七名接受根治性肿瘤治疗的淋巴瘤患者。其中三名患有霍奇金淋巴瘤，四名患有非霍奇金淋巴瘤，一名为女性，他们的平均年龄为51岁。患者在自行车测力计上以中等运动强度进行了10分钟的急性运动。在运动前休息时、运动结束后即刻以及运动后30分钟采集全血样本。使用流式细胞术测定白细胞亚群水平。运动结束后即刻，总白细胞中总自然杀伤（NK）细胞和CD56CD16 NK细胞的比例增加，并在运动后30分钟降至基线水平。运动结束后即刻，总T细胞中CD8 T细胞的比例增加，总T细胞中CD4 T细胞的比例下降，两者均在运动后30分钟恢复至基线水平。B细胞、粒细胞或单核细胞的比例没有变化。运动时的舒张压与总NK细胞和CD56CD16 NK细胞比例的变化呈正相关，运动时的平均动脉压与CD56CD16 NK细胞比例的变化呈正相关。我们的研究结果表明，仅10分钟的单次急性运动即可导致淋巴瘤患者出现白细胞增多，尤其是对细胞毒性T细胞和NK细胞而言，它们是对抗癌症的最重要免疫细胞。
