Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Elife. 2020 Oct 23;9:e59996. doi: 10.7554/eLife.59996.
Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces malignant tumor progression, and clinically, exercise can improve outcome for cancer patients. The etiology of the effects of exercise on tumor progression are unclear, as are the cellular actors involved. We show here that in mice, exercise-induced reduction in tumor growth is dependent on CD8+ T cells, and that metabolites produced in skeletal muscle and excreted into plasma at high levels during exertion in both mice and humans enhance the effector profile of CD8+ T-cells. We found that activated murine CD8+ T cells alter their central carbon metabolism in response to exertion in vivo, and that immune cells from trained mice are more potent antitumor effector cells when transferred into tumor-bearing untrained animals. These data demonstrate that CD8+ T cells are metabolically altered by exercise in a manner that acts to improve their antitumoral efficacy.
运动具有广泛的全身性效应。在动物模型中，反复运动可降低恶性肿瘤的进展，而临床研究表明，运动可以改善癌症患者的预后。运动对肿瘤进展影响的病因尚不清楚，涉及的细胞因子也不清楚。我们在这里表明，在小鼠中，运动引起的肿瘤生长减少依赖于 CD8+T 细胞，并且在小鼠和人类中，剧烈运动时骨骼肌产生并大量分泌到血浆中的代谢物可增强 CD8+T 细胞的效应器特征。我们发现，激活的小鼠 CD8+T 细胞会根据体内运动而改变其中心碳代谢，并且来自训练有素的小鼠的免疫细胞在转移到未经训练的荷瘤动物中时，更具抗肿瘤效应细胞的功能。这些数据表明，CD8+T 细胞通过运动以改善其抗肿瘤功效的方式发生代谢改变。
