Liu Zhigang, Liu Yuxia, Zhao Xiaofeng, Zhang Huijie, Feng Tingting, Pang Jianyue, Li Hengfen
Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Indian J Psychiatry. 2022 Nov-Dec;64(6):560-566. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_111_22. Epub 2022 Nov 30.
Major depressive disorder (MDD) is one of the most prevalent mental illnesses worldwide and involves cognitive dysfunction that may negatively impact clinical and social outcomes. Previous studies have suggested that beta-amyloid peptide (Aβ), DNA methyltransferase (Dnmt3a2), and urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) are associated with cognitive impairment. However, there are no relevant studies in MDD. The aim of this study was to assess the correlation between serum Aβ, Dnmt3a2, and urinary AD7c-NTP and cognitive dysfunction in MDD.
A total of 59 eligible patients were included in the study, including 29 patients with first-episode MDD (FEDs) and 30 patients with recurrent MDD (RMDDs), and 30 matched healthy controls (HCs) were selected. Participants' cognitive functioning was evaluated using the MATRICS consensus cognitive battery (MCCB). The enzyme-linked immunosorbent assay (ELISA) method was used to measure the concentrations of the three proteins. Statistical analysis was completed using Statistical Package for the Social Sciences (SPSS) 20.0. The statistical significance was set as < 0.05.
Serum Dnmt3a2 and urinary AD7c-NTP showed significant differences among the three groups (both < 0.001), but there were no significant differences in Aβ levels. Upon examining the results of cognitive testing, we found that serum Aβ was negatively associated with working memory scores in RMDDs ( = 0.020), but Dnmt3a2 was positively associated with working memory and verbal learning scores in the same cohort ( = 0.012 and = 0.037, respectively). In contrast, urinary AD7c-NTP was negatively correlated with verbal learning scores in FEDs ( = 0.013).
Serum Dnmt3a2 and Aβ levels may be associated with cognitive impairment in RMDDs and may act as potential biomarkers of cognitive impairment. Although urinary AD7c-NTP was closely related to cognitive dysfunction in FEDs, this relationship did not hold in RMDDs.
重度抑郁症（MDD）是全球最常见的精神疾病之一，伴有认知功能障碍，可能对临床和社会结局产生负面影响。先前的研究表明，β-淀粉样肽（Aβ）、DNA甲基转移酶（Dnmt3a2）和尿阿尔茨海默病相关神经元丝蛋白（AD7c-NTP）与认知障碍有关。然而，在MDD方面尚无相关研究。本研究的目的是评估血清Aβ、Dnmt3a2和尿AD7c-NTP与MDD认知功能障碍之间的相关性。
本研究共纳入59例符合条件的患者，包括29例首发MDD（FEDs）患者和30例复发性MDD（RMDDs）患者，并选取30例匹配的健康对照（HCs）。使用MATRICS共识认知成套测验（MCCB）评估参与者的认知功能。采用酶联免疫吸附测定（ELISA）法测量这三种蛋白质的浓度。使用社会科学统计软件包（SPSS）20.0完成统计分析。设定统计学显著性为<0.05。
血清Dnmt3a2和尿AD7c-NTP在三组之间存在显著差异（均<0.001），但Aβ水平无显著差异。在检查认知测试结果时，我们发现血清Aβ与RMDDs中的工作记忆得分呈负相关（=0.020），但Dnmt3a2与同一队列中的工作记忆和言语学习得分呈正相关（分别为=0.012和=0.037）。相比之下，尿AD7c-NTP与FEDs中的言语学习得分呈负相关（=0.013）。
血清Dnmt3a2和Aβ水平可能与RMDDs中的认知障碍有关，并可能作为认知障碍的潜在生物标志物。虽然尿AD7c-NTP与FEDs中的认知功能障碍密切相关，但这种关系在RMDDs中并不成立。
