Giedke H, Heimann H
Department of Psychiatry, University of Tübingen, FRG.
Pharmacopsychiatry. 1987 Sep;20(5):177-80. doi: 10.1055/s-2007-1017098.
Compared to 30 healthy controls, 59 drug free patients with primary major depression exhibited significantly higher rates of heart beat, respiration, and eye blinking; longer simple and associative reaction times; fewer spontaneous fluctuations of skin resistance, a lower salivation rate, a faster habituation rate of skin resistance orienting response, and a smaller CNV area in the EEG. Skin resistance level, speech pause time, N1P2 amplitudes of acoustically evoked potentials and the postimperative negative variation (PINV) in the EEG did not differ between groups. All deviations are nosologically unspecific; they can be regarded as signs of overarousal, as deficits, or as the result of protective inhibition. In all subjects the investigation was repeated twice, while the patients were treated with either amitriptyline or oxaprotiline, repetition of measurement influenced several variables, but most patient/control differences remained unaffected--irrespective of the drug applied.
与30名健康对照者相比，59名无药物治疗的原发性重度抑郁症患者表现出明显更高的心率、呼吸频率和眨眼频率；简单和联想反应时间更长；皮肤电阻的自发波动更少、唾液分泌率更低、皮肤电阻定向反应的习惯化率更快，以及脑电图中CNV区域更小。两组之间的皮肤电阻水平、言语停顿时间、听觉诱发电位的N1P2振幅和脑电图中的指令后负变化（PINV）没有差异。所有偏差在病因学上都是非特异性的；它们可被视为过度唤醒的迹象、缺陷或保护性抑制的结果。在所有受试者中，测量重复进行了两次，同时患者接受了阿米替林或奥沙普替林治疗，测量的重复影响了几个变量，但大多数患者/对照差异仍然不受影响——无论使用何种药物。
