Giedke H, Heimann H, Rein W
Universitäts Nervenklinik, Tübingen, RFA.
Rev Electroencephalogr Neurophysiol Clin. 1987 Sep;17(3):279-87. doi: 10.1016/s0370-4475(87)80065-5.
Using a simple S1S2-R paradigm, acoustically evoked potentials, CNV, and PINV were recorded in 59 patients with major depressive disorder before and during a 4 week double blind pharmacological treatment with either amitriptyline (AT) or oxaprotiline (OT). In parallel, 30 healthy subjects were investigated 3 times, in identical intervals of 2 weeks. In the depressed state patients exhibited significantly smaller CNVs than the controls. In the AT-group clinical improvement and drug plasma levels of nortriptyline (NT, the principal metabolite of AT and an active antidepressant by itself) were positively related to increases in CNV-area; in the OT-group the reverse was true: increase in CNV-area was related to smaller OT plasma levels and less favourable outcome. The control group displayed a steady decline in CNV area during the 3 test sessions. N1P2 amplitude and PINV were not significantly different between groups and exhibited only minor variations during treatment.
采用简单的S1S2-R范式，在59例重度抑郁症患者接受为期4周的阿米替林（AT）或奥沙普替林（OT）双盲药物治疗之前及治疗期间，记录听觉诱发电位、关联性负变（CNV）和晚负波（PINV）。同时，30名健康受试者每隔2周接受3次相同的检查。在抑郁状态下，患者的CNV明显小于对照组。在AT组，临床改善情况以及去甲替林（NT，AT的主要代谢产物，本身也是一种有效的抗抑郁药）的血药浓度与CNV面积的增加呈正相关；而在OT组，情况则相反：CNV面积的增加与OT血药浓度降低以及较差的治疗效果相关。对照组在3次测试期间CNV面积呈稳步下降。两组之间N1P2波幅和PINV无显著差异，且在治疗期间仅有微小变化。
