Hegerl U, Ulrich G, Müller-Oerlinghausen B
Department of Psychiatry, Free University of Berlin, Germany.
Pharmacopsychiatry. 1987 Sep;20(5):213-6. doi: 10.1055/s-2007-1017106.
Auditory evoked potentials were recorded in 28 euthymic patients with affective psychosis who had received lithium prophylaxis for at least 5 years. Binaural clicks at 4 intensities were presented in randomized order via headphones. Potentials were recorded from Cz, C3, and C4 referenced to linked mastoid electrodes. N1-P2 amplitudes, N1 and P2 latencies, and the slope of the amplitude/stimulus intensity function (ASF) were determined in each patient. The patients were divided into responders and nonresponders on the basis of whether or not they had been hospitalized for treatment of relapses during the last 5 years of lithium prophylaxis. The ASF was steeper for all leads in responders than in nonresponders. In addition, N1 latencies were shorter for all leads in responders than in nonresponders. Age played a role in the differences observed between responders and nonresponders for ASF, but not for N1 latencies.
对28名情感性精神病病情平稳的患者进行了听觉诱发电位记录，这些患者接受锂盐预防性治疗至少5年。通过耳机以随机顺序呈现4种强度的双耳点击声。从连接乳突电极的Cz、C3和C4记录电位。测定每位患者的N1-P2波幅、N1和P2潜伏期以及波幅/刺激强度函数（ASF）的斜率。根据在锂盐预防性治疗的最后5年中是否因复发住院治疗，将患者分为反应者和无反应者。反应者所有导联的ASF比无反应者更陡峭。此外，反应者所有导联的N1潜伏期比无反应者更短。年龄在反应者和无反应者之间观察到的ASF差异中起作用，但在N1潜伏期差异中不起作用。
