Hegerl U, Wulff H, Müller-Oerlinghausen B
Berlin Lithium Clinic, Department of Psychiatry, Freie Universität Berlin, Germany.
Psychiatry Res. 1992 Dec;44(3):181-90. doi: 10.1016/0165-1781(92)90022-u.
A predictor of clinical response to prophylactic lithium treatment in affective psychoses would be of considerable importance. In a pilot study, responders to prophylactic lithium medication, as compared with nonresponders, were characterized by a steeper slope of the amplitude/stimulus-intensity function (ASF slope) of the N1/P2 component of the auditory evoked potential. We tried to replicate this finding in 34 stabilized outpatients with affective illness who had been treated with lithium for at least 3 years. As in the pilot study, responders were again characterized by steeper ASF slopes than nonresponders. Since a steep ASF slope seems to indicate low central serotonergic function, it is speculated that a steep ASF slope characterizes those patients with a serotonin deficit who respond to serotonin agonists like lithium.
情感性精神病中预防性锂盐治疗临床反应的预测指标具有相当重要的意义。在一项初步研究中，与无反应者相比，预防性锂盐治疗有反应者的特征是听觉诱发电位N1/P2成分的振幅/刺激强度函数（ASF斜率）更陡。我们试图在34名稳定的情感性疾病门诊患者中重复这一发现，这些患者接受锂盐治疗至少3年。与初步研究一样，有反应者的ASF斜率再次比无反应者更陡。由于陡峭的ASF斜率似乎表明中枢血清素能功能低下，推测陡峭的ASF斜率是那些血清素缺乏且对锂盐等血清素激动剂有反应的患者的特征。
