2020 年加利福尼亚州人类临床烟曲霉分离株的基因组描述。
Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020.
机构信息
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
出版信息
Med Mycol. 2023 Feb 3;61(2). doi: 10.1093/mmy/myad012.
Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities in California. Single-nucleotide polymorphism (SNP) differences between patient isolates ranged from 187 to 70 829 SNPs. For five patients with multiple isolates, we calculated the within-host diversities. Three patients had a within-host diversity that ranged from 4 to 10 SNPs and two patients ranged from 2 to 16 977 SNPs. Findings revealed highly diverse A. fumigatus strains among patients and two patterns of diversity for isolates that come from the same patient, low and extremely high diversity.
烟曲霉是一种环境霉菌，可引起危及生命的感染。关于人类临床烟曲霉分离株的系统发育结构的研究有限。在这里，我们对从加利福尼亚州美国医疗机构的 18 名患者中收集的 24 株烟曲霉分离株进行了全基因组测序。患者分离株之间的单核苷酸多态性（SNP）差异范围为 187 至 70829 SNP。对于五个具有多个分离株的患者，我们计算了宿主内的多样性。三个患者的宿主内多样性范围为 4 至 10 个 SNP，两个患者的范围为 2 至 16977 SNP。研究结果表明，患者之间存在高度多样化的烟曲霉菌株，来自同一患者的分离株存在两种多样性模式，低多样性和极高多样性。
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