Department of Organic Chemistry, Shahid Beheshti University G.C., Tehran 1983963113, Iran.
Department of Biomedical Engineering, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
ACS Appl Bio Mater. 2022 Jan 17;5(1):40-58. doi: 10.1021/acsabm.1c01015. Epub 2021 Dec 14.
Covalent organic frameworks (COFs) are crystalline porous organic structures with two- or three-dimensional (2D or 3D) features and composed of building blocks being connected via covalent bonds. The manifold applications of COFs in optoelectronic devices, energy conversion and storage, adsorption, separation, sensing, organocatalysis, photocatalysis, electrocatalytic reactions, and biomedicine are increasing because of their notable intrinsic features such as large surface area, porosity, designable structure, low density, crystallinity, biocompatibility, and high chemical stability. These properties have rendered 2D and 3D COF-based materials as desirable entities for drug delivery, gene delivery, photothermal therapy, photodynamic therapy, combination therapy, biosensing, bioimaging, and anticancer activities. Herein, different reactions and methods for the synthesis of 2D and 3D COFs are reviewed with special emphasis on the construction and state-of-the-art progress pertaining to the biomedical applications of 2D and 3D COFs of varying shapes, sizes, and structures. Specifically, stimuli-responsive COFs-based systems and targeted drug delivery approaches are summarized.
共价有机框架（COFs）是具有二维或三维（2D 或 3D）特征的结晶多孔有机结构，由通过共价键连接的构建块组成。由于其显著的固有特性，如大表面积、多孔性、可设计的结构、低密度、结晶度、生物相容性和高化学稳定性，COFs 在光电设备、能量转换和存储、吸附、分离、传感、有机催化、光催化、电催化反应和生物医药中的应用正在增加。这些特性使得 2D 和 3D COF 基材料成为药物输送、基因输送、光热疗法、光动力疗法、联合疗法、生物传感、生物成像和抗癌活性的理想实体。本文综述了 2D 和 3D COFs 的不同合成反应和方法，并特别强调了不同形状、大小和结构的 2D 和 3D COFs 在生物医学应用方面的构建和最新进展。具体来说，总结了对刺激响应 COFs 基系统和靶向药物输送方法。
